Publication: Zinc supplementation does not inhibit basal and metoclopramide-stimulated prolactinemia secretion in healthy men
Loading...
Date
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Urban & Fischer Verlag
Type
Article
Access right
Acesso restrito
Abstract
Dopamine (DA) and zinc (Zn++) share common mechanisms in their inhibition of prolactin (PRL) secretion. Both substances are present in the same brain areas, where Zn++ is released together with DA, suggesting a modulatory effect of Zn++ on dopaminergic receptors. The aim of the present study was to evaluate the effect of Zn supplementation on basal and PRL secretion stimulated by metoclopramide (MCP), a dopaminergic antagonist. Seven healthy men were evaluated in controlled study, where MCP (5 mg) was given intravenously, before and after 3 months of oral Zn++ (25 mg) administration. Our results indicate that chronic Zn++ administration does not change basal or MCP-stimulated plasma PRL secretion suggesting that, in humans, Zn++ does not interfere on PRL secretion mediated through dopaminergic receptors.
Description
Keywords
zinc supplementation, prolactin secretion, metoclopramide, healthy men
Language
English
Citation
Journal of Trace Elements In Medicine and Biology. Jena: Urban & Fischer Verlag, v. 16, n. 2, p. 69-73, 2002.
