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Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease

dc.contributor.authorZambrano, Laura M. G. [UNESP]
dc.contributor.authorBrandao, Dayane A. [UNESP]
dc.contributor.authorRocha, Fernanda R. G. [UNESP]
dc.contributor.authorMarsiglio, Raquel P. [UNESP]
dc.contributor.authorLongo, Ieda B. [UNESP]
dc.contributor.authorPrimo, Fernando L. [UNESP]
dc.contributor.authorTedesco, Antonio C.
dc.contributor.authorGuimaraes-Stabili, Morgana R. [UNESP]
dc.contributor.authorRossa, Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:19:45Z
dc.date.available2018-12-11T17:19:45Z
dc.date.issued2018-12-01
dc.description.abstractThere is evidence indicating that curcumin has multiple biological activities, including anti-inflammatory properties. In vitro and in vivo studies demonstrate that curcumin may attenuate inflammation and the connective tissue destruction associated with periodontal disease. Most of these studies use systemic administration, and considering the site-specific nature of periodontal disease and also the poor pharmacodynamic properties of curcumin, we conducted this proof of principle study to assess the biological effect of the local administration of curcumin in a nanoparticle vehicle on experimental periodontal disease. We used 16 rats divided into two groups of 8 animals according to the induction of experimental periodontal disease by bilateral injections of LPS or of the vehicle control directly into the gingival tissues 3×/week for 4 weeks. The same volume of curcumin-loaded nanoparticles or of nanoparticle vehicle was injected into the same sites 2×/week. μCT analysis showed that local administration of curcumin resulted in a complete inhibition of inflammatory bone resorption and in a significant decrease of both osteoclast counts and of the inflammatory infiltrate; as well as a marked attenuation of p38 MAPK and NF-kB activation. We conclude that local administration of curcumin-loaded nanoparticles effectively inhibited inflammation and bone resorption associated with experimental periodontal disease.en
dc.description.affiliationDepartment of Diagnosis and Surgery School of Dentistry at Araraquara-Univ Estadual Paulista (UNESP)
dc.description.affiliationFaculty of Pharmaceutical Sciences of Araraquara Department of Bioprocess and Biotechnology Sao Paulo State University (UNESP)
dc.description.affiliationDepartment of Chemistry Center of Nanotechnology and Tissue Engineering Photobiology and Photomedicine Research Group Faculty of Philosophy Sciences and Letters of Ribeirao Preto University of Sao Paulo
dc.description.affiliationUnespDepartment of Diagnosis and Surgery School of Dentistry at Araraquara-Univ Estadual Paulista (UNESP)
dc.description.affiliationUnespFaculty of Pharmaceutical Sciences of Araraquara Department of Bioprocess and Biotechnology Sao Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1038/s41598-018-24866-2
dc.identifier.citationScientific Reports, v. 8, n. 1, 2018.
dc.identifier.doi10.1038/s41598-018-24866-2
dc.identifier.file2-s2.0-85046134524.pdf
dc.identifier.issn2045-2322
dc.identifier.scopus2-s2.0-85046134524
dc.identifier.urihttp://hdl.handle.net/11449/176243
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.relation.ispartofsjr1,533
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.titleLocal administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal diseaseen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationca4c0298-cd82-48ee-a9c8-c97704bac2b0
relation.isOrgUnitOfPublication.latestForDiscoveryca4c0298-cd82-48ee-a9c8-c97704bac2b0
unesp.author.lattes7634063102292261[9]
unesp.author.orcid0000-0003-1705-5481[9]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentDiagnóstico e Cirurgia - FOARpt

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