Sister-chromatid exchanges in β-thalassaemic patients under conditions of in vivo and in vitro depletion of folic acid
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In order to investigate the effect of folate depletion, lymphocyte sister-chromatid exchange (SCE) rates were compared among homozygous β-thalassaemic patients with low folic acid levels, heterozygous β-thalassaemic patients with normal folate levels and healthy persons with normal haemoglobin, in cultures with both normal and depleted folate conditions. Significantly higher SCE rates were found in homozygous patients in all assays, but the in vitro folate depletion did not induce an increase in SCE frequency in any group.
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β-Thalassaemia Culture conditions Follic acid Sister-chromatid exchange folic acid beta thalassemia clinical article controlled study heterozygote homozygote human human cell lymphocyte culture priority journal sister chromatid exchange Adolescent Adult Analysis of Variance Cells, Cultured Child Child, Preschool Folic Acid Deficiency Human Infant Lymphocytes Sister Chromatid Exchange Support, Non-U.S. Gov't Thalassemia
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Mutation Research - Mutation Research Letters, v. 282, n. 3, p. 213-217, 1992.
