Logo do repositório
 

Healing and expression of growth factors (TGF-β and PDGF) in canine radial ostectomy gap containing platelet-rich plasma

dc.contributor.authorSouza, Talita F. B. [UNESP]
dc.contributor.authorAndrade, Alexandre L. [UNESP]
dc.contributor.authorFerrreira, G. T. N. M. [UNESP]
dc.contributor.authorSakamoto, Silmara Sanae [UNESP]
dc.contributor.authorAlbuquerque, Verônica Batista de [UNESP]
dc.contributor.authorBonfim, S. R. M. [UNESP]
dc.contributor.authorLuvizotto, Maria Cecilia Rui [UNESP]
dc.contributor.authorLouzada, Mario Jefferson Quirino [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:53:40Z
dc.date.available2016-01-28T16:53:40Z
dc.date.issued2012
dc.description.abstractObjectives: To evaluate bone healing in an experimental radial ostectomy in dogs treated with autologous platelet-rich plasma (PRP), through histological, densitometric, radiographic studies, as well as expression of growth factors in the ostectomy gap. Methods: Twenty-one dogs were randomly divided into either a control or a PRP group. All underwent unilateral ostectomy of the radius to generate a gap of 2.0 mm, that was stabilized with external skeletal fixation. The ostectomy gap was either filled with PRP or left empty as a control. The radiographic and densitometric studies were performed after surgery, then at intervals until 60 days during the post-surgery period. Histological and immunohistochemical evaluations were performed at seven or 60 days post-surgery. Analyses were performed using a statistical analysis system, and the level of significance was set at p <0.05. Results: The median radiographic healing score in the PRP group increased significantly between day 0 and day 60. Furthermore, at 60 days, the median healing score and the proportion of healed ostectomies in the control group (score 1; 1/6 healed) and the PRP group (score 5; 4/5 healed) were significantly different. There were differences between groups in radiographic and densitometric values at days 45 and 60. The histological evaluation showed advanced bone healing at 60 days in the PRP group and signs of delayed union in the control group. Clinical relevance: Platelet-rich plasma can be used as an adjuvant therapy because it may promote better bone healing of a radial ostectomy treated with external skeletal fixation in dogs.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária de Araçatuba, Departamento de Clínica, Cirurgia e Reprodução Animal, RUA CLÓVIS PESTANA, 793, D. Amélia, CEP 16050680, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária de Araçatuba, Departamento de Clínica, Cirurgia e Reprodução Animal, RUA CLÓVIS PESTANA, 793, D. Amélia, CEP 16050680, SP, Brasil
dc.format.extent445-452
dc.identifierhttp://dx.doi.org/10.3415/VCOT-10-10-0146
dc.identifier.citationVeterinary and Comparative Orthopaedics and Traumatology, v. 25, n. 6, p. 445-452, 2012.
dc.identifier.doi10.3415/VCOT-10-10-0146
dc.identifier.issn0932-0814
dc.identifier.lattes6404176495306171
dc.identifier.lattes2925649195052339
dc.identifier.lattes4584674909952477
dc.identifier.urihttp://hdl.handle.net/11449/133109
dc.language.isoeng
dc.relation.ispartofVeterinary and Comparative Orthopaedics and Traumatology
dc.relation.ispartofjcr0.872
dc.relation.ispartofsjr0,726
dc.rights.accessRightsAcesso restrito
dc.sourceCurrículo Lattes
dc.subjectDogsen
dc.subjectPlatelet-rich plasmaen
dc.subjectTGF-βen
dc.subjectPlatelet growth factorsen
dc.subjectPDGFen
dc.subjectExperimental ostectomyen
dc.subjectTransforming growth factor betaen
dc.titleHealing and expression of growth factors (TGF-β and PDGF) in canine radial ostectomy gap containing platelet-rich plasmaen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes6404176495306171[2]
unesp.author.lattes2925649195052339
unesp.author.lattes4584674909952477
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária, Araçatubapt
unesp.departmentClínica, Cirurgia e Reprodução Animal - FMVApt

Arquivos