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The Rv1712 locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially Phosphorylates dCMP

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dc.contributor.authorThum, Caroline
dc.contributor.authorSchneider, Cristopher Z.
dc.contributor.authorPalma, Mario Sergio [UNESP]
dc.contributor.authorSantos, Diógenes S.
dc.contributor.authorBasso, Luiz A.
dc.contributor.institutionPontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:53Z
dc.date.available2014-05-27T11:23:53Z
dc.date.issued2009-04-01
dc.description.abstractThe Mycobacterium tuberculosis cmk gene, predicted to encode a CMP kinase (CMK), was cloned and expressed, and its product was purified to homogeneity. Steady-state kinetics confirmed that M. tuberculosis CMK is a monomer that preferentially phosphorylates CMP and dCMP by a sequential mechanism. A plausible role for CMK is discussed. Copyright © 2009, American Society for Microbiology. All Rights Reserved.en
dc.description.affiliationCentro de Pesquisas em Biologia Molecular e Funcional Instituto Nacional de Ciência e Tecnologia em Tuberculose Pontificia Universidade Católica do Rio Grande do Sul, Av. Ipiranga 6681, Porto Alegre, RS 90619-900
dc.description.affiliationPrograma de Pós-Graduação em Biologia Celular e Molecular Pontificia Universidade Católica do Rio Grande do Sul, Av. Ipiranga 6681, Porto Alegre, RS 90619-900
dc.description.affiliationLaboratório de Biologia Estrutural e Zooquímica Centro de Estudos de Insetos Sociais Universidade Estadual Paulista-Rio Claro, SP13506-900
dc.description.affiliation, Av. Ipiranga 6681, Tecnopuc-Predio 92A, Porto Alegre, RS 90619-900
dc.description.affiliationUnespLaboratório de Biologia Estrutural e Zooquímica Centro de Estudos de Insetos Sociais Universidade Estadual Paulista-Rio Claro, SP13506-900
dc.format.extent2884-2887
dc.identifierhttp://dx.doi.org/10.1128/JB.01337-08
dc.identifier.citationJournal of Bacteriology, v. 191, n. 8, p. 2884-2887, 2009.
dc.identifier.doi10.1128/JB.01337-08
dc.identifier.file2-s2.0-65249143233.pdf
dc.identifier.issn0021-9193
dc.identifier.lattes2901888624506535
dc.identifier.scopus2-s2.0-65249143233
dc.identifier.urihttp://hdl.handle.net/11449/70966
dc.language.isoeng
dc.relation.ispartofJournal of Bacteriology
dc.relation.ispartofjcr3.219
dc.relation.ispartofsjr1,885
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectcytidine phosphate kinase
dc.subjectdeoxycytidine phosphate
dc.subjectmonomer
dc.subjectphosphotransferase
dc.subjectunclassified drug
dc.subjectcytidylate kinase
dc.subjectnucleoside monophosphate kinase
dc.subjectrecombinant protein
dc.subjectbacterial gene
dc.subjectbacterial strain
dc.subjectcontrolled study
dc.subjectenzyme kinetics
dc.subjectenzyme phosphorylation
dc.subjectgene expression
dc.subjectgene locus
dc.subjectgenetic code
dc.subjectmolecular cloning
dc.subjectMycobacterium tuberculosis
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectprotein function
dc.subjectprotein purification
dc.subjectsteady state
dc.subjectamino acid sequence
dc.subjectenzymology
dc.subjectgenetics
dc.subjectisolation and purification
dc.subjectkinetics
dc.subjectmetabolism
dc.subjectmolecular genetics
dc.subjectphosphorylation
dc.subjectsequence alignment
dc.subjectAmino Acid Sequence
dc.subjectCloning, Molecular
dc.subjectDeoxycytidine Monophosphate
dc.subjectGene Expression
dc.subjectKinetics
dc.subjectMolecular Sequence Data
dc.subjectNucleoside-Phosphate Kinase
dc.subjectPhosphorylation
dc.subjectRecombinant Proteins
dc.subjectSequence Alignment
dc.titleThe Rv1712 locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially Phosphorylates dCMPen
dc.typeArtigo
dcterms.licensehttp://journals.asm.org/site/misc/ASM_Author_Statement.xhtml
dspace.entity.typePublication
unesp.author.lattes2901888624506535
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
unesp.departmentBiologia - IBpt

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