Estudo dos aspectos clínico, laboratorial, histopatológico e do tratamento na intoxicação experimental pelo veneno da serpente Crotalus durissus terrificus em cães
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Data
2004
Autores
Nogueira, Rosa Maria Barilli [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
O presente trabalho teve por objetivo avaliar os aspectos clínico, laboratorial, histopatológico e tratamento na intoxicação experimental com o veneno da serpente Crotalus durissus terrificus em cães. Foram utilizados 21 cães, adultos, sem raça definida, divididos em três grupos com sete animais: grupo I - somente veneno; grupo II - veneno + cinco ampolas de soro antiofídico + fluidoterapia; grupo III - veneno + cinco ampolas de soro antiofídico + fluidoterapia + alcalinização da urina. O veneno da serpente Crotalus durissus terrificus liofolizado e reconstituído em solução salina foi inoculado pela via subcutânea, na dose de 1mg/kg de peso vivo, na face lateral da coxa do membro posterior esquerdo dos cães dos grupos I, II e III. Os animais foram submetidos às avaliações clínica, hematológica, hemostática, urinálise, bioquímica sérica, hemogasometria, pressão arterial sistólica, eletrocardiograma e mielograma. Três animais de cada grupo foram eutanasiados e foram colhidas amostras do tecido muscular para avaliação histopatológica. Os resultados mostraram a eficácia da soroterapia na neutralização do veneno e mostrou que o veneno da serpente Crotalus durissus terrificus provoca alterações clínica, hematológica, hemostática, de urinálise, hemogasométrica, da pressão arterial sistólica, do mielograma e histopatológica nos cães. Não houve evidências de alterações eletrocardiográficas e bioquímica.
This work evaluated the clinical, laboratorial, histological and treatment in the experimental intoxication with the venom of the Crotalus durissus terrificus snake in dogs. Twenty-one adults (mixed breed) dogs divided in three groups with seven animals were used: group I - only venom; group II - venom + five bladders of anti-ophidic serum + fluid therapy; group III - venom + five bladders of anti-ophidic serum + fluid therapy + alkalization of the urine. The lyophilized venom of the Crotalus durissus terrificus snake was reconstituted in saline solution and inoculated subcutaneous, in the dose of 1mg/kg B.W., in the lateral face of the left thigh of the dogs of the groups I, II and III. The animals were submitted to clinical, hematological evaluation, hemostatic, urinalysis, biochemical, blood gas analysis, systolic arterial pressure, electrocardiogram and mielograma. Three animals of each group were eutanasied and samples from the muscular tissue and popliteal lymphonode were collected for hitopatological evaluation. The results showed the effectiveness of the serum therapy in the neutralization of the venom and it showed that the venom of the Crotalus durissus terrificus snake causes clinical, hematological, hemostatic, of urinary, hemogasometric changes, of the systolic arterial pressure, of the mielograma and histopathological in the dogs. There were no evidences of alterations eletrocardiografic and biochemical alterations.
This work evaluated the clinical, laboratorial, histological and treatment in the experimental intoxication with the venom of the Crotalus durissus terrificus snake in dogs. Twenty-one adults (mixed breed) dogs divided in three groups with seven animals were used: group I - only venom; group II - venom + five bladders of anti-ophidic serum + fluid therapy; group III - venom + five bladders of anti-ophidic serum + fluid therapy + alkalization of the urine. The lyophilized venom of the Crotalus durissus terrificus snake was reconstituted in saline solution and inoculated subcutaneous, in the dose of 1mg/kg B.W., in the lateral face of the left thigh of the dogs of the groups I, II and III. The animals were submitted to clinical, hematological evaluation, hemostatic, urinalysis, biochemical, blood gas analysis, systolic arterial pressure, electrocardiogram and mielograma. Three animals of each group were eutanasied and samples from the muscular tissue and popliteal lymphonode were collected for hitopatological evaluation. The results showed the effectiveness of the serum therapy in the neutralization of the venom and it showed that the venom of the Crotalus durissus terrificus snake causes clinical, hematological, hemostatic, of urinary, hemogasometric changes, of the systolic arterial pressure, of the mielograma and histopathological in the dogs. There were no evidences of alterations eletrocardiografic and biochemical alterations.
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Palavras-chave
Serpente peçonhenta - Veneno - Efeito fisiológico
Como citar
NOGUEIRA, Rosa Maria Barilli. Estudo dos aspectos clínico, laboratorial, histopatológico e do tratamento na intoxicação experimental pelo veneno da serpente Crotalus durissus terrificus em cães. 2004. 178 f. Tese (doutorado) - Universidade Estadual Paulista, Faculdade de Medicina Veterinária e Zootecnia, 2004.