Alterações comportamentais, psicológicas, de higiene bucal e presença de microrganismos superinfectantes e viruses da família herpesviridae em pacientes mantidas em programa de desintoxicação para dependentes químicos
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Data
2009-05-06
Autores
Lins, Sâmira Ambar [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
A dependência de drogas traz sérias conseqüências sistêmicas, econômicas e sociais. Assim, o presente estudo objetivou avaliar a ocorrência de enfermidades em pacientes do gênero feminino com dependência química e a possibilidade da cavidade bucal dessas pacientes se converter em reservatório de microrganismos oportunistas.. Para tanto, foram obtidos dados referentes às condições de saúde sistêmicas, socioeconômicas, consumo de medicamentos, uso de drogas lícitas ou ilícitas de 50 pacientes com dependência química mantidas internadas em clínica de desintoxicação, o mesmo ocorrendo com igual número de pacientes não dependentes. A seguir, foram realizados exames clínicos intra e extrabucais. Amostras de biofilme supra e subgengivais, saliva e das mucosas foram transferidas para água ultrapura. A ocorrência da família Enterobacteriaceae, Enterococcus sp., E. faecalis, E. faecium, Pseudomonas sp., P. aeruginosa e Candida spp., Helicobacter e H. pylori, bem como os viruses HSV-1, CMV e EBV-1 foi avaliada por PCR ou nested PCR. Verificou-se que 94% das pacientes do grupo teste eram usuárias de mais do que uma única droga, sendo o tabaco (92%), bebidas alcoólicas (68%), crack (66%) e cocaína (52%) as mais consumidas, quase sempre em múltiplas associações. Verificou-se maior freqüência de alterações comportamentais e/ou psicológicas no grupo teste, além de dores articulares, infecções oportunistas, cefaléia, fadiga, xerostomia, formigamento das extremidades, anemia, periodontite, perda de peso, retardo do processo de reparo, entre outras. Observou-se freqüência significavente mais elevada de Candida sp., C. albicans, família Enterobacteriaceae, Enterococcus sp., Helicobacter sp., H. pylori, vírus CMV e vírus EBV-1 na saliva das pacientes com dependência química, enquanto no biofilme supragengival verificou-se...
Drug addiction frequently causes serious systemic, economic and social consequences. Thus, the present study aimed at evaluating the occurrence of illnesses in female chemically dependent patients as well as the possibility of their oral cavity becoming potential reservoir for opportunistic microorganisms. For this purpose, data regarding systemic health and socioeconomic status, medication consumption, legal or illegal drug use were obtained from 50 female chemically dependent patients undergoing inpatient detoxification treatment; while the same procedure was carried out with 50 non-addicted females. Subsequently, intra and extra-oral clinical tests were done. Samples from the supra- and subgingival biofilms, saliva and oral mucosa were transferred to ultrapure water. The occurrence of Enterobacteriaceae family, Enterococcus sp., E. faecalis, E. faecium, Pseudomonas sp., P. aeruginosa and Candida sp., Helicobacter and H. pylori, as well as viruses HSV-1, CMV and EBV-1 was evaluated by using PCR or nested PCR. It was verified that 94% of the patients from the chemically dependent group were multiple drug users, being tobacco (92%), alcohol (68%), crack (66%) and cocaine (52%) the most consumed ones. A higher frequency of behavioral and/or psychological alterations was verified in the chemically dependent group, besides articular pain, opportunistic infections, headaches, fatigue, xerostomy, tingling extremities, anemia, periodontitis, weight loss, delay in the repair process, among others. A higher frequency of Candida sp., C. albicans, Enterobacteriaceae family, Enterococcus sp., Helicobacter sp., H. pylori, CMV and EBV-1 viruses was observed in the saliva from the chemically dependent group; while in the supragingival biofilm a higher proportion of positive samples to Candida sp., C. albicans, Enterobacteriaceae family, Enterococcus sp., E. faecalis, Helicobacter... (Complete abstract click electronic access below)
Drug addiction frequently causes serious systemic, economic and social consequences. Thus, the present study aimed at evaluating the occurrence of illnesses in female chemically dependent patients as well as the possibility of their oral cavity becoming potential reservoir for opportunistic microorganisms. For this purpose, data regarding systemic health and socioeconomic status, medication consumption, legal or illegal drug use were obtained from 50 female chemically dependent patients undergoing inpatient detoxification treatment; while the same procedure was carried out with 50 non-addicted females. Subsequently, intra and extra-oral clinical tests were done. Samples from the supra- and subgingival biofilms, saliva and oral mucosa were transferred to ultrapure water. The occurrence of Enterobacteriaceae family, Enterococcus sp., E. faecalis, E. faecium, Pseudomonas sp., P. aeruginosa and Candida sp., Helicobacter and H. pylori, as well as viruses HSV-1, CMV and EBV-1 was evaluated by using PCR or nested PCR. It was verified that 94% of the patients from the chemically dependent group were multiple drug users, being tobacco (92%), alcohol (68%), crack (66%) and cocaine (52%) the most consumed ones. A higher frequency of behavioral and/or psychological alterations was verified in the chemically dependent group, besides articular pain, opportunistic infections, headaches, fatigue, xerostomy, tingling extremities, anemia, periodontitis, weight loss, delay in the repair process, among others. A higher frequency of Candida sp., C. albicans, Enterobacteriaceae family, Enterococcus sp., Helicobacter sp., H. pylori, CMV and EBV-1 viruses was observed in the saliva from the chemically dependent group; while in the supragingival biofilm a higher proportion of positive samples to Candida sp., C. albicans, Enterobacteriaceae family, Enterococcus sp., E. faecalis, Helicobacter... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Microbiologia, Bacterias, Virus, Infecção, Transtornos relacionados ao uso de substâncias, Substance-Related Disorders, Microbiology, Bacteria, Viruses, Infection
Como citar
LINS, Sâmira Ambar. Alterações comportamentais, psicológicas, de higiene bucal e presença de microrganismos superinfectantes e viruses da família herpesviridae em pacientes mantidas em programa de desintoxicação para dependentes químicos. 2009. 97 f. Tese (doutorado) - Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, 2009.