Avaliação do fluxo salivar total não estimulado durante e após radioterapia, com o uso do lauril-dietileno-glicol-éter-sulfato de sódio associado ao hidróxido de cálcio
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Data
2006-12-18
Autores
Correia, Christiano Marinho [UNESP]
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Universidade Estadual Paulista (Unesp)
Resumo
Os tratamentos utilizados para a prevenção da xerostomia não atingem a eficácia esperada pelos pacientes, podendo ainda produzir efeitos colaterais indesejáveis. O objetivo deste trabalho foi avaliar quantitativamente o índice de fluxo salivar total não estimulado de pacientes portadores de câncer de cabeça e pescoço durante e após tratamento radioterápico exclusivo tratados com a associação de laurildietileno- glicol-éter-sulfato de sódio e hidróxido de cálcio (HcT20). Este estudo foi realizado no Hospital Dr. Hélio Angotti envolvendo trinta e um pacientes (n=31) divididos em dois grupos: o grupo I composto por dezessete pacientes (n=17) submetidos à telecobaltoterapia, na dose total de 7.000 cGy e receberam o HcT20 durante o tratamento. O grupo II composto por quatorze pacientes (n=14) iniciaram o uso do HcT20 após a conclusão da radioterapia. Foram realizadas e mensuradas coletas semanais do índice de fluxo salivar total não estimulado para os pacientes dos dois grupos. Os valores obtidos foram analisados estatisticamente através dos testes de aderência à curva normal, teste de Bartlett, teste de Friedman e teste de Wilcoxon, visando avaliar a eficácia do HcT20 tanto na prevenção da queda acentuada do fluxo salivar durante a radioterapia quanto na hipofunção salivar no período pós-radioterapia. Os pacientes do grupo I, ao término da radioterapia, mantiveram o índice de fluxo salivar total não estimulado em relação aos valores basais; os do grupo II, que utilizaram a associação medicamentosa após radioterapia, apresentaram melhora acentuada no índice de fluxo salivar total não estimulado em relação ao basal; e o uso do HcT20 apresentou melhor resultado quando utilizado durante a radioterapia.
The treatments used to prevent the xerostomy do not reach the efficiency expected by the patients, and it can have undesirable effects. The goal of this report was to make a quantifiable evaluation of the total non stimulated salivary flow index in patients with head and neck cancers during and after the exclusive radiotherapy with an association of lauryl-diethylene-glycol-ether sodium sulfate and calcium hydroxide (HcT20). This study was held at the hospital Dr. Hélio Angotti involving thirty one patients (n=31) divided into two groups: Group one had seventeen patients (n=17) submitted to fractioned radiation treatment in the head and neck region at the total dose of 7.000 cGy and had HcT20 during the treatment. Group two with fourteen patients (n=14) started with the use of HcT20 after the end of radiotherapy. A weekly and measured collection of the index of the total non stimulated saliva flow was done on the patients of both groups. The values that were obtained were analyzed statistically through the Bartlett test, the Friedman test and the Wilcoxon test, to seek an evaluation of the effectiveness of the medication on the prevention of the intense drop of the salivary flow during the radiotherapy and do avoid the xerostomy during the postradiotherapeutic period. The patients from group one at the end of the radiotherapy kept the base index of the total non stimulated salivary flow, the ones from group two that used the medication association after the radiotherapy had a great improvement of the total non stimulated salivary flow and the usage of HcT20 had a better result on the index of salivary flow during the radiotherapy.
The treatments used to prevent the xerostomy do not reach the efficiency expected by the patients, and it can have undesirable effects. The goal of this report was to make a quantifiable evaluation of the total non stimulated salivary flow index in patients with head and neck cancers during and after the exclusive radiotherapy with an association of lauryl-diethylene-glycol-ether sodium sulfate and calcium hydroxide (HcT20). This study was held at the hospital Dr. Hélio Angotti involving thirty one patients (n=31) divided into two groups: Group one had seventeen patients (n=17) submitted to fractioned radiation treatment in the head and neck region at the total dose of 7.000 cGy and had HcT20 during the treatment. Group two with fourteen patients (n=14) started with the use of HcT20 after the end of radiotherapy. A weekly and measured collection of the index of the total non stimulated saliva flow was done on the patients of both groups. The values that were obtained were analyzed statistically through the Bartlett test, the Friedman test and the Wilcoxon test, to seek an evaluation of the effectiveness of the medication on the prevention of the intense drop of the salivary flow during the radiotherapy and do avoid the xerostomy during the postradiotherapeutic period. The patients from group one at the end of the radiotherapy kept the base index of the total non stimulated salivary flow, the ones from group two that used the medication association after the radiotherapy had a great improvement of the total non stimulated salivary flow and the usage of HcT20 had a better result on the index of salivary flow during the radiotherapy.
Descrição
Palavras-chave
Tumores odontogenicos, Hidroxido de calcio, Radioterapia, Salivação, Neoplasias bucais, Neoplasias orofaríngeas, Dodecilsulfato de sódio, Salivation, Mouth neoplasms, Sodium dodecyl sulfate, Calcium hydroxide, Radiotherapy
Como citar
CORREIA, Christiano Marinho. Avaliação do fluxo salivar total não estimulado durante e após radioterapia, com o uso do lauril-dietileno-glicol-éter-sulfato de sódio associado ao hidróxido de cálcio. 2006. 73 f. Tese (doutorado) - Universidade Estadual Paulista, Faculdade de Odontologia de Araçatuba, 2006.