Investigação estrutural e efeitos imunológicos e tuberculostáticos de complexos de paládio(II)
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Data
2009-02-18
Autores
Stevanato, Alessandra [UNESP]
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Editor
Universidade Estadual Paulista (Unesp)
Resumo
O presente trabalho teve como objetivo a síntese de compostos de paládio(II) utilizando como reagentes o acetato de paládio(II), o cloreto de paládio(II), a Nbenzilidenoanilina (bzan), a N,N-dimetilbenzilamina (dmba), os sais KCl, KBr, KSCN, KNCO e NaN3 para posterior formação das espécies precursoras, a saber: [Pd(bzan)(μ-X)]2, X = Cl, SCN, NCO e N3 e [Pd(dmba)(μ-X)]2, X = Cl, Br, NCO e N3. A obtenção de novos compostos a partir dos dímeros anteriores ocorreu empregando ligantes contendo fósforo como átomo doador, tais como as difosfinas 1,1’- bis(difenilfosfina)ferroceno (dppf) e a cis-1,2-bis(difenilfosfina)etileno (dppet). A escolha destes ligantes foi norteada por suas relevantes propriedades farmacológicas. O ligante isonicotinamida (isn), que contem nitrogênio como átomo doador, foi escolhido devido à sua semelhança estrutural com a isoniazida, já utilizada como droga antituberculostática. Estes ligantes foram selecionados com o intuito de aplicar seus complexos de paládio(II) em testes biológicos. Ressalte-se a repreparação dos complexos do tipo [Pd(bzan)(X)(dppp)], X = Cl, SCN, NCO e N3 e a 1,3-bis(difenilfosfina)propano (dppp), para seu emprego em testes antitumorais utilizando linhagens humanas e em testes contra o bacilo de Koch, causador da tuberculose. Esta repreparação possibilitou a obtenção de um monocristal do composto [Pd(bzan)(SCN)(dppp)].CDCl3 e a difração de raios-X de monocristal forneceu todas as características estruturais da espécie no estado sólido, mostrando uma geometria quadrado planar ao redor do átomo de paládio(II), a coordenação do ligante bzan pelo átomo de carbono, havendo a clivagem da ligação entre o paládio e o nitrogênio imínico da bzan presente nas espécies precursoras diméricas, o pseudohaleto coordena-se terminalmente via átomo de enxofre (Pd-SCN) e a difosfina dppp coordena-se ao centro metálico...
The aim of this research was the synthesis of palladium(II) compounds by using as reagents palladium(II) acetate, palladium(II) chloride, N-benzylideneaniline (bzan), N,Ndimethylbenzylamine (dmba) and the salts KCl, KBr, KSCN, KNCO and NaN3 for the subsequent preparation of the precursor species [Pd(bzan)(μ-X)]2, X = Cl, SCN, NCO e N3, and [Pd(dmba)(μ-X)]2, X = Cl, Br, NCO e N3. The obtainment of new compounds from the previously cited dimers was performed by reacting them with ligands containing phosphorous as the donor atom, like the diphosphines 1,1’-bis(diphenylphosphine)ferrocene (dppf) and cis 1,2- bis(diphenylphosphine)ethylene (dppet). These ligands were chosen due to their relevant pharmacological properties. Isonicotinamide, a ligand containing nitrogen as donor atom, was chosen due to its structural resemblance with isoniazid, used as a antituberculostatic drug. These ligands were selected with the intention of applying their complexes in biological tests. The known compounds of the type [Pd(bzan)(X)(dppp)], X = Cl, SCN, NCO and N3 and dppp = 1,3-bis(diphenylphosphine)propane, were reprepared in order to be applied in antitumor tests with human cells and in tests against the Koch bacillus, which causes tuberculosis. These repreparations allowed us the obtainment of single-crystals of the compound [Pd(bzan)(SCN)(dppp)].CDCl3 and the single-crystal X-ray diffraction technique gave us all of its structural features in the solid state, showing a square-planar geometry around the palladium(II) atom; the pseudohalide is terminally coordinated by the sulphur atom (Pd-SCN), the diphosphine is bound in the chelating mode and the bzan ligand is coordinated by the carbon atom, revealing the cleavage of the bond between the palladium and the iminic nitrogen from the bzan, present in the dimmeric precursor species. The knowledge of this structure supported the structural purposes... (Complete abstract click electronic access below)
The aim of this research was the synthesis of palladium(II) compounds by using as reagents palladium(II) acetate, palladium(II) chloride, N-benzylideneaniline (bzan), N,Ndimethylbenzylamine (dmba) and the salts KCl, KBr, KSCN, KNCO and NaN3 for the subsequent preparation of the precursor species [Pd(bzan)(μ-X)]2, X = Cl, SCN, NCO e N3, and [Pd(dmba)(μ-X)]2, X = Cl, Br, NCO e N3. The obtainment of new compounds from the previously cited dimers was performed by reacting them with ligands containing phosphorous as the donor atom, like the diphosphines 1,1’-bis(diphenylphosphine)ferrocene (dppf) and cis 1,2- bis(diphenylphosphine)ethylene (dppet). These ligands were chosen due to their relevant pharmacological properties. Isonicotinamide, a ligand containing nitrogen as donor atom, was chosen due to its structural resemblance with isoniazid, used as a antituberculostatic drug. These ligands were selected with the intention of applying their complexes in biological tests. The known compounds of the type [Pd(bzan)(X)(dppp)], X = Cl, SCN, NCO and N3 and dppp = 1,3-bis(diphenylphosphine)propane, were reprepared in order to be applied in antitumor tests with human cells and in tests against the Koch bacillus, which causes tuberculosis. These repreparations allowed us the obtainment of single-crystals of the compound [Pd(bzan)(SCN)(dppp)].CDCl3 and the single-crystal X-ray diffraction technique gave us all of its structural features in the solid state, showing a square-planar geometry around the palladium(II) atom; the pseudohalide is terminally coordinated by the sulphur atom (Pd-SCN), the diphosphine is bound in the chelating mode and the bzan ligand is coordinated by the carbon atom, revealing the cleavage of the bond between the palladium and the iminic nitrogen from the bzan, present in the dimmeric precursor species. The knowledge of this structure supported the structural purposes... (Complete abstract click electronic access below)
Descrição
Palavras-chave
Química inorgânica, Atividade biológica, Complexos de paládio (II), Inorganic chemistry
Como citar
STEVANATO, Alessandra. Investigação estrutural e efeitos imunológicos e tuberculostáticos de complexos de paládio(II). 2009. 178 f. Tese (doutorado) - Universidade Estadual Paulista, Instituto de Química, 2009.