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dc.contributor.authorRegasini, L. O. [UNESP]
dc.contributor.authorLopes,, A. A. [UNESP]
dc.contributor.authorSilva, D. H.S. [UNESP]
dc.contributor.authorFurlan, Maysa [UNESP]
dc.contributor.authorYoung, M. C.M.
dc.contributor.authorMaria, D. A.
dc.contributor.authorBarreiro,, E. J.
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.date.accessioned2014-06-24T19:53:46Z
dc.date.available2014-06-24T19:53:46Z
dc.date.issued2007
dc.identifierhttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/252
dc.identifier.citationRevista de Ciências Farmacêuticas Básica e Aplicada, v. 28, n. 3, 2007, p. 335-340.
dc.identifier.issn1808-4532
dc.identifier.issn2179-443X
dc.identifier.urihttp://hdl.handle.net/11449/106970
dc.description.abstractAs part of our program of bioprospecting for novel antitumor drug prototypes, twenty extracts and fractions obtained from Pterogyne nitens Tul. (Fabaceae, Caesalpinioideae) were screened for antiproliferative activity against B16F10 murine melanoma cells, by the MTT colorimetric assay. The strongest activity was found in EtOAc fractions from the flowers (IC50 = 0.35 µg/mL), fruits (IC50 = 0.34 µg/mL), leaves (IC50 = 0.33 µg/mL) and stems (IC50 = 0.29 µg/mL). Analysis by TLC and HPLC-DAD showed the presence of guanidine alkaloids, flavones and flavonols in the bioactive samples. Additionally, a phytochemical study of the EtOAc fraction of the stems afforded quercetin (1) and isoquercitrin (2), two flavonols with antiproliferative activity previously described in the literature. On the basis of these results, it can be concluded that P. nitens inhibits the growth of melanoma cells in vitro. Further investigations will be needed to assess the usefulness of the samples under study for the treatment of neoplasms and to characterize other bioactive compounds. Keywords: antiproliferative; Pterogyne nitens; Caesalpinioideae; melanoma; flavonoids; Fabaceae.en
dc.language.isoeng
dc.publisherUniversidade Estadual Paulista (UNESP)
dc.relation.ispartofRevista de Ciências Farmacêuticas Básica e Aplicada
dc.sourceRevista de Ciências Farmacêuticas Básica e Aplicada
dc.subjectCiências Farmacêuticaspt
dc.subjectFarmáciapt
dc.subjectFarmacologiapt
dc.subjectToxicologiapt
dc.subjectBotânica médicapt
dc.subjectPlantas medicinaispt
dc.subjectAtenção Farmacêuticapt
dc.subjectAssistência farmacêuticapt
dc.subjectIndústria Farmacêutica.pt
dc.subjectantiproliferativept
dc.subjectPterogyne nitenspt
dc.subjectCaesalpinioideaept
dc.subjectmelanomapt
dc.subjectflavonoidspt
dc.subjectFabaceae.pt
dc.subjectMelanonapt
dc.titleAntiproliferative effect of Pterogyne nitens on melanoma cellsen
dc.typeArtigo
dcterms.licensehttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/about
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionInstituto de Botânica, São Paulo
dc.contributor.institutionInstituto Butantan
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.description.affiliationDepartamento de Química Orgânica, NuBBE, Instituto de Química, Universidade Estadual Paulista, UNESP, Araraquara, SP, Brasil.
dc.description.affiliationSeção de Fisiologia e Bioquímica de Plantas, Instituto de Botânica, São Paulo, SP, Brasil.
dc.description.affiliationServiço de Bioquímica, Divisão de Ciências Fisiológicas e Químicas, Instituto Butantan, São Paulo, SP, Brasil.
dc.description.affiliationFaculdade de Farmácia, LASSBio, Universidade Federal do Rio de Janeiro, UFRJ, Rio de Janeiro, RJ, Brasil.
dc.description.affiliationUnespDepartamento de Química Orgânica, NuBBE, Instituto de Química, Universidade Estadual Paulista, UNESP, Araraquara, SP, Brasil.
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-50049089104
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
dc.identifier.fileISSN1808-4532-2007-28-3-335-340.pdf
dc.identifier.lattes1308042794786872
dc.identifier.lattes4484083685251673
unesp.author.lattes1308042794786872
unesp.author.lattes4484083685251673
dc.relation.ispartofsjr0,131
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