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dc.contributor.authorAndrade, N. S.
dc.contributor.authorPerazzo, F. F.
dc.contributor.authorMaistro, Edson Luis [UNESP]
dc.date.accessioned2014-05-20T13:31:44Z
dc.date.available2014-05-20T13:31:44Z
dc.date.issued2008-01-01
dc.identifierhttp://dx.doi.org/10.4238/vol7-4gmr546
dc.identifier.citationGenetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 7, n. 4, p. 1414-1421, 2008.
dc.identifier.issn1676-5680
dc.identifier.urihttp://hdl.handle.net/11449/10809
dc.description.abstractBaccharis dracunculifolia de Candole (DC) ( Asteraceae) is indigenous throughout southeastern Latin America and is used by local people in traditional medicine. This plant is known to be the source of resin for the highly valued Brazilian green propolis. As no information is available on the safety of high doses of B. dracunculifolia extract, we evaluated the mutagenic potential of high doses of this plant extract in vivo on peripheral blood cells of Swiss mice using the comet assay and the micronucleus test. The extract was administered by gavage at doses of 1000, 1500 and 2000 mg/kg body weight. Peripheral blood cell samples were collected 4 and 24 h after treatment for the comet assay (genotoxicity assay), and at 48 and 72 h for the micronucleus test (clastogenicity assay). The B. dracunculifolia extract was devoid of clastogenic/genotoxic activity at all doses.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1414-1421
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics and Molecular Research
dc.sourceWeb of Science
dc.subjectBaccharis dracunculifoliaen
dc.subjectMicronucleus testen
dc.subjectSingle cell gel electrophoresisen
dc.subjectMutagenicity assayen
dc.titleLack of clastogenic/genotoxic effects of Baccharis dracunculifolia extract on Swiss mouse peripheral blood cellsen
dc.typeArtigo
dcterms.licensehttp://www.geneticsmr.com/node/2
dcterms.rightsHolderFunpec-editora
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Jose Rosario Vellano
dc.contributor.institutionUniversidade Federal do Amapá (UNIFAP)
dc.description.affiliationUniv Estadual Paulista, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP, Brazil
dc.description.affiliationUniv Jose Rosario Vellano, Genet Lab, Alfenas, MG, Brazil
dc.description.affiliationUniv Fed Amapa, Lab Pesquisa Farmacos, Macapa, AP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP, Brazil
dc.identifier.doi10.4238/vol7-4gmr546
dc.identifier.wosWOS:000267218200032
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 06/57514-2
dc.description.sponsorshipIdFAPEMIG: 1879/02
dc.description.sponsorshipIdCNPq: 306544/2006-7
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Maríliapt
dc.identifier.fileWOS000267218200032.pdf
dc.identifier.lattes4787521613038315
dc.identifier.orcid0000-0003-0757-7876
unesp.author.lattes4787521613038315[3]
unesp.author.orcid0000-0003-0757-7876[3]
dc.relation.ispartofsjr0,439
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