Effect of intravenous alizapride on spinal morphine-induced pruritus
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Data
2003-08-01
Autores
Horta, M. L.
Vianna, PTG
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Editor
Oxford University Press
Resumo
Background. This double-blind study was undertaken to determine whether alizapride inhibits spinal morphine-induced pruritus.Methods. Eighty-four patients undergoing Caesarean section under spinal anaesthesia (100 mg of hyperbaric lidocaine 5% plus morphine 0.2 mg) were randomly allocated to one of two groups. just after birth, alizapride-50 mg (alizapride group) or metoclopramide 10 mg (metoclopramide group) were injected i.v. Patients were assessed after surgery for pruritus (absent, mild, moderate or severe) or other untoward symptoms.Results. In the metoclopramide group, pruritus was absent in 5 (12%) patients, mild in 23 (55%), moderate in 11 (26%), and severe in 3 (7%), while in the alizapride group, these incidences were, respectively, 5 (12%), 33 (79%), 4 (10%), and 0 (P=0.045, chi(2)-test). There was no difference in the incidence of side-effects, which were all minor.Conclusions. Alizapride reduced the severity of morphine-induced pruritus.
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anaesthesia, obstetric, analgesics opioid, morphine, complications, pruritus, pharmacology, alizapride
Como citar
British Journal of Anaesthesia. Oxford: Oxford Univ Press, v. 91, n. 2, p. 287-289, 2003.