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dc.contributor.authorFerrari, Fabio [UNESP]
dc.contributor.authorLiu, Zhi-Hai
dc.contributor.authorLu, Qin
dc.contributor.authorBecquemin, Marie-Helene
dc.contributor.authorLouchahi, Kamel
dc.contributor.authorAymard, Guy
dc.contributor.authorMarquette, Charles-Hugo
dc.contributor.authorRouby, Jean-Jacques
dc.identifier.citationIntensive Care Medicine. New York: Springer, v. 34, n. 9, p. 1718-1723, 2008.
dc.description.abstractObjective: To compare the efficiency of an Aeroneb Pro vibrating plate and an Atomisor MegaHertz ultrasonic nebulizer for providing ceftazidime distal lung deposition.Design: In vitro experiments. One gram of cetazidime was nebulized in respiratory circuits and mass median aerodynamic diameter of particles generated by ultrasonic and vibrating plate nebulizers was compared using a laser velocimeter. In vivo experiments. Lung tissue concentrations and extrapulmonary depositions were measured in ten anesthetized ventilated piglets with healthy lungs that received 1 g of ceftazidime by nebulization with either an ultrasonic (n = 5), or a vibrating plate (n = 5) nebulizer.Setting: A two-bed Experimental Intensive Care Unit of a University School of Medicine.Intervention: Following sacrifice, 5 subpleural specimens were sampled in dependent and nondependent lung regions for measuring ceftazidime lung tissue concentrations by high-performance liquid chromatography.Measurements and results: Mass median aerodynamic diameters generated by both nebulizers were similar with more than 95% of the particles between 0.5 and 5 mu m. Lung tissue concentrations were 553 +/- 123 [95% confidence interval: 514-638] mu g g(-1) using ultrasonic nebulizer, and 452 +/- 172 [95% confidence interval: 376-528] mu g g(-1) using vibrating plate nebulizers (NS). Extrapulmonary depositions were, respectively, of 38 +/- 5% (ultrasonic) and 34 +/- 4% (vibrating plate) (NS).Conclusions: Vibrating plate nebulizer is comparable to ultrasonic nebulizers for ceftazidime nebulization. It may represent a new attractive technology for inhaled antibiotic therapy.en
dc.description.sponsorshipAerogen Nektar Corporation, Galway, Ireland
dc.relation.ispartofIntensive Care Medicine
dc.sourceWeb of Science
dc.subjectvibrating plateen
dc.subjectnebulization of antibioticsen
dc.subjectlung tissue concentrationen
dc.titleComparison of lung tissue concentrations of nebulized ceftazidime in ventilated piglets: ultrasonic versus vibrating plate nebulizersen
dc.contributor.institutionLa Pitie Salpetriere Hosp
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionZhejiang Univ
dc.contributor.institutionUniv Paris 06
dc.contributor.institutionDenis Diderot Univ
dc.contributor.institutionAvicenne Hosp
dc.contributor.institutionUniv Rech Expt
dc.contributor.institutionUniv Lille
dc.description.affiliationLa Pitie Salpetriere Hosp, Dept Anesthesia & Crit Care, Reanimat Chirurg Polyvalente Pierre Viars, F-75013 Paris, France
dc.description.affiliationUniv Estadual Paulista, Fac Med, Dept Anesthesiol, Botucatu, SP, Brazil
dc.description.affiliationZhejiang Univ, Sch Med, Dept Emergency Med, Affiliated Hosp 2, Hangzhou 310027, Peoples R China
dc.description.affiliationUniv Paris 06, La Pitie Salpetriere Hosp, Dept Anesthesiol & Crit Care Med, AP HP,Surg Intens Care Unit Pierre Viars, Paris, France
dc.description.affiliationDenis Diderot Univ, La Salpetriere Hosp, AP HP, Dept Resp Physiol, F-2397 Paris, France
dc.description.affiliationAvicenne Hosp, AP HP, Dept Pharmacol, Bobigny, France
dc.description.affiliationLa Pitie Salpetriere Hosp, AP HP, Dept Pharmacol, Paris, France
dc.description.affiliationUniv Rech Expt, Dept Hosp, Lille, France
dc.description.affiliationUniv Lille, INSERM U416, Inst Pasteur, Lille, France
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med, Dept Anesthesiol, Botucatu, SP, Brazil
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unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt[7][8]
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