Luminescent threat: toxicity of light stick attractors used in pelagic fishery
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2014-06-19
Autores
Oliveira, Tiago Franco de
Medeiros da Silva, Amanda Lucila
Moura, Rafaela Alves de
Bagattini, Raquel [UNESP]
Falcao de Oliveira, Antonio Anax
Gennari de Medeiros, Marisa Helena
Di Mascio, Paolo
Arruda Campos, Ivan Persio de [UNESP]
Barretto, Fabiano Prado
Henriques Bechara, Etelvino Jose
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Nature Publishing Group
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Light sticks (LS) are sources of chemiluminescence commonly used in pelagic fishery, where hundreds are discarded and reach the shores. Residents from fishing villages report an improper use of LS contents on the skin. Given the scarce information regarding LS toxicity, the effects of LS solutions in cell cultures were evaluated herein. Loss of viability, cell cycle changes and DNA fragmentation were observed in HepG2 cell line and skin fibroblasts. A non-cytotoxic LS concentration increased the occurrence of the mutagenic lesion 1,N-6-epsilon dAdo in HepG2 DNA by three-fold. Additionally, in vitro incubations of spent LS contents with DNA generated dGuo-LS adducts, whose structure elucidation revealed the presence of a reactive chlorinated product. In conclusion, the LS contents were found to be highly cyto- and genotoxic. Our data indicate an urgent need for LS waste management guidelines and for adequate information regarding toxic outcomes that may arise from human exposure.
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Scientific Reports. London: Nature Publishing Group, v. 4, 11 p., 2014.