• Pitfalls and challenges of the purinergic signaling cascade in obesity 

  de Oliveira, Miriane ; Mathias, Lucas Solla ; de Sibio, Maria Teresa ; Noronha-Matos, José Bernardo; Costa, Maria Adelina; Nogueira, Célia Regina ; Correia-de-Sá, Paulo (Biochemical Pharmacology, 2020) [Resenha]

  Obesity is a worldwide health problem which have reached pandemic proportions, now also including low and middle-income countries. Excessive or abnormal fat deposition in the abdomen especially in the visceral compartment ...

• Clinical utility of a traditional score system for the evaluation of the peritoneal dialysis exit-site infection in a national multicentric cohort study 

  Rigo, Mariane; Pecoits-Filho, Roberto; Lambie, Mark; Tuon, Felipe Francisco; Barretti, Pasqual ; de Moraes, Thyago Proença (Peritoneal Dialysis International, 2020) [Artigo]

  Introduction: Exit-site infection (ESI) is an important risk factor for peritonitis in patients under chronic peritoneal dialysis (PD). The International Society for Peritoneal Dialysis (ISPD) recommend its diagnosis as ...

• Decreased collagen type i is associated with increased metalloproteinase-2 activity and protein expression of leptin in the myocardium of obese rats 

  da Silva-Bertani, Danielle Cristina Tomaz ; Vileigas, Danielle Fernandes ; Mota, Gustavo Augusto Ferreira ; de Souza, Sérgio Luiz Borges ; De Tomasi, Loreta Casquel ; de Campos, Dijon Henrique Salomé ; de Deus, Adriana Fernandes ; Freire, Paula Paccielli ; Alves, Carlos Augusto Barnabe ; Padovani, Carlos Roberto et al. (Arquivos Brasileiros de Cardiologia, 2020) [Artigo]

  Background: Obesity is a risk factor for medical complications, including the cardiovascular system. There is limited information on collagen in the heart in obesity. Our previous study showed decreased protein levels of ...

• Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture 

  de Oliveira, Miriane ; De Sibio, Maria Teresa ; Mathias, Lucas Solla ; Rodrigues, Bruna Moretto ; Sakalem, Marna Eliana; Nogueira, Célia Regina (Molecular and Cellular Endocrinology, 2020) [Artigo]

  Obesity patients are more susceptible to develop COVID-19 severe outcome due to the role of angiotensin-converting enzyme 2 (ACE2) in the viral infection. ACE2 is regulated in the human cells by different genes associated ...

• Effects of aerobic and resistance exercise on cardiac remodelling and skeletal muscle oxidative stress of infarcted rats 

  Gomes, Mariana J. ; Pagan, Luana U. ; Lima, Aline R. R. ; Reyes, David R. A. ; Martinez, Paula F.; Damatto, Felipe C. ; Pontes, Thierres H. D. ; Rodrigues, Eder A. ; Souza, Lidiane M. ; Tosta, Ingrid F. et al. (Journal of Cellular and Molecular Medicine, 2020) [Artigo]

  We compared the influence of aerobic and resistance exercise on cardiac remodelling, physical capacity and skeletal muscle oxidative stress in rats with MI-induced heart failure. Three months after MI induction, Wistar ...

• Euterpe oleracea mart. (açaí) reduces oxidative stress and improves energetic metabolism in myocardial ischemia-reperfusion injury in rats 

  Alegre, Patricia ; Mathias, Livia ; Lourenço, Maria Angelica ; Dos Santos, Priscila Portugal ; Gonçalves, Andrea ; Fernandes, Ana Angélica ; Gaiolla, Paula Schmidt Azevedo ; Minicucci, Marcos Ferreira ; Zornoff, Leonardo ; Paiva, Sergio Alberto Rupp et al. (Arquivos Brasileiros de Cardiologia, 2020) [Artigo]

  Background: Euterpe oleracea Mart. (açaí) is a fruit with high antioxidant capacity and could be an adjuvant strategy to attenuate ischemia-reperfusion injury. Objective: To evaluate the influence of açaí in global ...

• The roles of triiodothyronine and irisin in improving the lipid profile and directing the browning of human adipose subcutaneous cells 

  de Oliveira, Miriane ; Mathias, Lucas Solla ; Rodrigues, Bruna Moretto ; Mariani, Bianca Gonçalves ; Graceli, Jones Bernardes; De Sibio, Maria Teresa ; Castro Olimpio, Regiane Marques ; Fontes Moretto, Fernanda Cristina ; Deprá, Igor Carvalho ; Nogueira, Célia Regina (Molecular and Cellular Endocrinology, 2020) [Artigo]

  Triiodothyronine (T3) and irisin (I) can modulate metabolic status, increase heat production, and promote differentiation of white adipose tissue (WAT) into brown adipose tissue (BAT). Herein, human subcutaneous white ...

• Triiodothyronine activated extranuclear pathways upregulate adiponectin and leptin in murine adipocytes 

  Mathias, Lucas Solla ; Rodrigues, Bruna Moretto ; Gonçalves, Bianca Mariani ; Moretto, Fernanda Cristina Fontes ; Olimpio, Regiane Marques Castro ; Deprá, Igor ; De Sibio, Maria Teresa ; Tilli, Helena Paim ; Nogueira, Célia Regina ; de Oliveira, Miriane (Molecular and Cellular Endocrinology, 2020) [Artigo]

  Adiponectin and leptin, important for metabolic regulation, are synthesized and secreted by adipose tissue and are influenced by triiodothyronine (T3) that activates the MAPK/ERK and integrin αVβ3 pathways, modulating gene ...

• Enhanced expression of NLRP3 inflammasome components by monocytes of patients with pulmonary paracoccidioidomycosis is associated with smoking and intracellular hypoxemia 

  Amorim, Barbara Casella ; Pereira-Latini, Ana Carla; Golim, Márjorie de Assis ; Ruiz Júnior, Raul Lopes ; Yoo, Hugo Hyung Bok ; Arruda, Maria Sueli Parreira de ; Tavares, Aldo Henrique; Cavalcante, Ricardo de Souza ; Mendes, Rinaldo Poncio ; Pontillo, Alessandra et al. (Microbes and Infection, 2020) [Artigo]

  Paracoccidioidomycosis (PCM) is a systemic mycosis caused by thermally dimorphic fungi of the genus Paracoccidioides that affects predominantly 30-60-year-old male rural workers. The main clinical forms of the disease are ...

• Phylogenetic species of paracoccidioides spp. Isolated from clinical and environmental samples in a hyperendemic area of paracoccidioidomycosis in Southeastern Brazil 

  Cocio, Tiago A.; Nascimento, Erika; Kress, Marcia R. von Zeska; Bagagli, Eduardo ; Martinez, Roberto (Journal of Fungi, 2020) [Artigo]

  Paracoccidioides brasiliensis complex and P. lutzii are the etiological agents of paracoccidioidomycosis. The geographic distribution of these species in South America is still poorly comprehended. Fifty samples of ...

• EPILAT-IRA study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America 

  Lombardi, Raúl; Ferreiro, Alejandro; Granado, Rolando Claure-Del; Burdmann, Emmanuel A.; Rosa-Diez, Guillermo; Yu, Luis; Younes-Ibrahim, Mauricio; Carlino, Cristina; Chávez-Iñiguez, Jonathan S.; Pereira, Mariana B. et al. (PLoS ONE, 2019) [Artigo]

  Introduction Epidemiology of acute kidney injury (AKI) is highly dependent on patient characteristics, context and geography. Considering the limited information in Latin America and the Caribbean, we performed a study ...

• A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas 

  Sant’ Anna, B. G.; Musolino, N. R.C.; Gadelha, M. R.; Marques, C.; Castro, M.; Elias, P. C.L.; Vilar, L.; Lyra, R.; Martins, M. R.A.; Quidute, A. R.P. et al. (Pituitary, 2020) [Artigo]

  Objective: To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort. Methods: The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital ...

• Dieta Intermitente Atenua a Remodelação Cardíaca Causada pelo Exercício Físico 

  Basilio, Priscilla Gois; Oliveira, Ana Priscila Cayres de; Castro, Ana Carolini Ferreira de; Carvalho, Marianna Rabelo de; Zagatto, Alessandro Moura ; Martinez, Paula Felippe; Okoshi, Marina Politi ; Okoshi, Katashi ; Ota, Gabriel Elias; Reis, Filipe Abdalla Dos et al. (Arquivos brasileiros de cardiologia, 2020) [Artigo]

  BACKGROUND: The effects of non-pharmacological interventions such as calorie restriction and exercise training on health and prevention of cardiovascular diseases have been investigated in clinical and experimental studies. ...

• Does COVID-19 Increase the Risk for Spontaneous Pneumothorax? 

  do Lago, Vanessa Carvalho ; Cezare, Talita Jacon ; Fortaleza, Carlos Magno Castelo Branco ; Okoshi, Marina Politi ; Baldi, Bruno Guedes; Tanni, Suzana Erico (American Journal of the Medical Sciences, 2020) [Carta]

• Long-term follow-up of patients undergoing decompressive hemicraniectomy for malignant stroke: Quality of life and caregiver's burden in a real-world setting 

  Hamamoto Filho, Pedro Tadao ; Gonçalves, Lucas Braz ; Koetz, Nicholas Falcomer ; Silvestrin, Aline Maria Lara ; Alves Júnior, Aderaldo Costa ; Rocha, Lilian Aline ; Módolo, Gabriel Pinheiro ; de Avila, Marla Andréia Garcia ; Martin, Luis Cuadrado ; Neugebauer, Hermann et al. (Clinical Neurology and Neurosurgery, 2020) [Artigo]

  Background and Purpose: Decompressive hemicraniectomy is a life-saving procedure for the treatment of space-occupying middle cerebral artery infarctions (malignant stroke); however, patients may survive severely disabled. ...

• Hidradenitis suppurativa as a paradoxical side effect to the use of adalimumab in patients with crohn’s disease? 

  Beraldo, Rodrigo Fedatto ; Marcondes, Mariana Barros ; Baima, Julio Pinheiro ; Barros, Jaqueline Ribeiro ; Ramdeen, Madhoor; Saad-Hossne, Rogerio ; Sassaki, Ligia Yukie (Clinical and Experimental Gastroenterology, 2020) [Artigo]

  Background: Hidradenitis suppurativa is a chronic inflammatory skin disorder associated with inflammatory bowel disease. However, it can arise as a paradoxical side effect of antiTNF treatment. Methods: The article reports ...

• Risk factors for ulcerative colitis-associated colorectal cancer: A retrospective cohort study 

  de Campos Silva, Elen Farinelli ; Baima, Julio Pinheiro ; de Barros, Jaqueline Ribeiro ; Tanni, Suzana Erico ; Schreck, Thomas; Saad-Hossne, Rogerio ; Sassaki, Ligia Yukie (Medicine, 2020) [Artigo]

  Inflammatory bowel disease is associated with an increased risk of colorectal cancer. The study aims to identify the risk factors for ulcerative colitis-colorectal cancer and to perform a survival curve analysis of the ...

• Impact of Modality and Intensity of Early Exercise Training on Ventricular Remodeling after Myocardial Infarction 

  Batista, Diego Fernando ; Polegato, Bertha Furlan ; Da Silva, Renata Candido ; Claro, Renan Turini ; Azevedo, Paula Shmidt ; Fernandes, Ana Angélica ; Okoshi, Katashi ; De Paiva, Sergio Alberto Rupp ; Minicucci, Marcos Ferreira ; Zornorff, Leonardo Antônio Mamede (Oxidative Medicine and Cellular Longevity, 2020) [Artigo]

  The objective of this study was to analyze the impact of different modalities and intensities of exercise training on cardiac remodeling started early after experimental myocardial infarction (MI). Male Wistar rats, weighing ...

• Comments on 'Adult height after gonadotropin-releasing hormone agonist treatment in girls with early puberty: A meta-analysis' 

  Antunes Franzini, Italo ; Massahito Yamamoto, Fabio ; Bolfi, Fernanda ; Rauber Antonini, Sonir Roberto; Nunes-Nogueira, Vania dos Santos (Clinical Endocrinology, 2020) [Carta]

• No Benefit of Hemostatic Drugs on Acute Upper Gastrointestinal Bleeding in Cirrhosis 

  An, Yang; Bai, Zhaohui; Xu, Xiangbo; Guo, Xiaozhong; Romeiro, Fernando Gomes ; Philips, Cyriac Abby; Li, Yingying; Wu, Yanyan; Qi, Xingshun (BioMed Research International, 2020) [Artigo]

  Background and Aims. Acute upper gastrointestinal bleeding (AUGIB) is one of the most life-threatening emergency conditions. Hemostatic drugs are often prescribed to control AUGIB in clinical practice but have not been ...

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