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dc.contributor.authorCezar, Marcelo D. M. [UNESP]
dc.contributor.authorDamatto, Ricardo L. [UNESP]
dc.contributor.authorMartinez, Paula F.
dc.contributor.authorLima, Aline R. R. [UNESP]
dc.contributor.authorCampos, Dijon H. S. [UNESP]
dc.contributor.authorRosa, Camila M. [UNESP]
dc.contributor.authorGuizoni, Daniele M. [UNESP]
dc.contributor.authorBonomo, Camila [UNESP]
dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.contributor.authorGimenes, Rodrigo [UNESP]
dc.contributor.authorPagan, Luana U. [UNESP]
dc.contributor.authorOkoshi, Marina Politi [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.date.accessioned2014-12-03T13:10:29Z
dc.date.available2014-12-03T13:10:29Z
dc.date.issued2013-01-01
dc.identifierhttp://dx.doi.org/10.1159/000354526
dc.identifier.citationCellular Physiology And Biochemistry. Basel: Karger, v. 32, n. 5, p. 1275-1287, 2013.
dc.identifier.issn1015-8987
dc.identifier.urihttp://hdl.handle.net/11449/112184
dc.description.abstractBackground: The role of aldosterone blockers during transition from long-term compensated hypertrophy to dilated failure is not completely understood. In this study we evaluated the effects of early administration of spironolactone on cardiac remodeling, myocardial function, and mortality in spontaneously hypertensive rats (SHR). Methods: Sixteen-month-old SHR received no treatment (SHR-C, n=72) or spironolactone (SHR-SPR, 20 mg/kg/day, n=34) for six months. Echocardiogram was performed before and after treatment. Myocardial function was analyzed in left ventricular (LV) papillary muscle preparations. Myocardial collagen aund hydroxyproline concentration were evaluated by morphometry and spectrophotometry, respectively. LV gene expression was assessed by real time RT-PCR. Statistics: Student's t test; Log rank test (Kaplan Meyer). Results: SHR-C and SHR-SPR presented mortality rates of 71 and 38%, respectively (p=0.004). Systolic arterial pressure did not differ between groups (SHR-C 199 +/- 43; SHR-SPR 200 +/- 35 mmHg). Initial and final echocardiograms did not show significant differences in cardiac structures or LV function between groups. Myocardial function was similar between groups at basal and after inotropic stimulation. Collagen fractional area, hydroxyproline concentration, gene expression for alpha- and beta-myosin heavy chain, atrial natriuretic peptide, and Serca2a were not different between groups. Conclusion: Early spironolactone administration reduces mortality without changing cardiac remodeling in spontaneous hypertensive rats. Copyright (C) 2013 S. Karger AG, Baselen
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1275-1287
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofCellular Physiology and Biochemistry
dc.sourceWeb of Science
dc.subjectHeart failureen
dc.subjectMyocardial functionen
dc.subjectEchocardiogramen
dc.subjectSpironolactoneen
dc.subjectVentricular functionen
dc.subjectPapillary muscleen
dc.titleAldosterone Blockade Reduces Mortality without Changing Cardiac Remodeling in Spontaneously Hypertensive Ratsen
dc.typeArtigo
dcterms.licensehttp://www.karger.com/Services/RightsPermissions
dcterms.rightsHolderKarger
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.description.affiliationSao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUNESP, Botucatu Med Sch, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUniv Fed Mato Grosso do Sul, Campo Grande, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Botucatu Med Sch, BR-18618970 Botucatu, SP, Brazil
dc.identifier.doi10.1159/000354526
dc.identifier.wosWOS:000328699600014
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdCNPq: 305013/2009-0
dc.description.sponsorshipIdCNPq: 304998/2009-5
dc.description.sponsorshipIdFAPESP: 07/57497-3
dc.description.sponsorshipIdFAPESP: 09/54407-9
dc.description.sponsorshipIdFAPESP: 09/54506-7
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.fileWOS000328699600014.pdf
dc.identifier.lattes9418970103564137
dc.identifier.lattes4463138671998432
dc.identifier.lattes1590971576309420
unesp.author.lattes9418970103564137[9]
unesp.author.lattes4463138671998432
unesp.author.lattes1590971576309420
unesp.author.orcid0000-0001-8980-8839[13]
unesp.author.orcid0000-0002-2579-5247[8]
unesp.author.orcid0000-0002-4402-6523[9]
dc.relation.ispartofjcr5.500
dc.relation.ispartofsjr1,561
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