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dc.contributor.authorZerbini Guimaraes, Carolina Okada
dc.contributor.authorMiot, Hélio Amante [UNESP]
dc.contributor.authorBagatin, Edileia
dc.date.accessioned2014-12-03T13:10:31Z
dc.date.available2014-12-03T13:10:31Z
dc.date.issued2014-06-01
dc.identifierhttp://dx.doi.org/10.1111/dsu.0000000000000024
dc.identifier.citationDermatologic Surgery. Hoboken: Wiley-blackwell, v. 40, n. 6, p. 610-617, 2014.
dc.identifier.issn1076-0512
dc.identifier.urihttp://hdl.handle.net/11449/112214
dc.description.abstractBACKGROUND The antimetabolite 5-fluorouracil (5-FU) is used for topical treatment of actinic keratosis. Overall improvement in the skin is also observed. Additionally, 5-FU was reported to be used for superficial peels.OBJECTIVES To evaluate the efficacy and safety of 5% 5-FU cream compared with peels for photodamaged forearms.METHODS This interventional, randomized, comparative, evaluator-blind study included 32 patients with severe photoaging of forearms. The regimens comprised either application of 5% 5-FU cream everyday for 4 weeks on 1 forearm and 4 weekly peels on the other. Efficacy assessment included: clinical photodamage scores, opinion of patients and investigators, and blind photographic evaluation by independent observers. Skin biopsies were performed for histologic and immunohistochemical analysis. Safety evaluation comprised observation of adverse events.RESULTS Clinical and histologic findings confirmed the benefits of topical 5% 5-FU, in cream or peels, which improved skin appearance and decreased the dermal elastotic material. Immunohistochemistry showed reduced levels of epidermal p53 and increase in the level of procollagen I. Results were maintained after 6 months. Predictable adverse events occurred, with no differences between treatments. Patients reported better tolerability to peels.CONCLUSION Five percent 5-FU cream or peels was safe and effective for the treatment of photodamaged forearms. Decreased epidermal p53 levels and new dermal collagen were confirmed.en
dc.format.extent610-617
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofDermatologic Surgery
dc.sourceWeb of Science
dc.titleFive Percent 5-Fluorouracil in a Cream or for Superficial Peels in the Treatment of Advanced Photoaging of the Forearms: A Randomized Comparative Studyen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationFed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, Brazil
dc.description.affiliationState Univ Sao Paulo UNESP, Dept Dermatol, Botucatu, SP, Brazil
dc.description.affiliationUnespState Univ Sao Paulo UNESP, Dept Dermatol, Botucatu, SP, Brazil
dc.identifier.doi10.1111/dsu.0000000000000024
dc.identifier.wosWOS:000337708400002
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.lattes2543633050941005
unesp.author.lattes2543633050941005
unesp.author.orcid0000-0002-2596-9294[2]
dc.relation.ispartofjcr2.471
dc.relation.ispartofsjr1,168
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