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dc.contributor.authorGoncalves Zorzella-Pezavento, Sofia Fernanda [UNESP]
dc.contributor.authorChiuso-Minicucci, Fernanda [UNESP]
dc.contributor.authorDonega Franca, Thais Graziela [UNESP]
dc.contributor.authorWatanabe Ishikawa, Larissa Lumi [UNESP]
dc.contributor.authorRosa, Larissa Camargo da [UNESP]
dc.contributor.authorColavite, Priscila Maria [UNESP]
dc.contributor.authorMarques, Camila
dc.contributor.authorValerio Ikoma, Maura Rosane
dc.contributor.authorSilva, Celio Lopes
dc.contributor.authorSartori, Alexandrina [UNESP]
dc.identifier.citationJournal Of Neuroimmunology. Amsterdam: Elsevier Science Bv, v. 268, n. 1-2, p. 35-42, 2014.
dc.description.abstractMost of the therapeutic strategies to control multiple sclerosis are directed to immune modulation and inflammation control. As heat shock proteins are able to induce immunoregulatory T cells, we investigated the therapeutic effect of a genetic vaccine containing the mycobacterial hsp65 gene on experimental autoimmune encephalomyelitis (EAE). Although pVAXhsp65 was immunogenic for mice with EAE and downmodulated specific cytokine induction by MOG, therapy was not able to decrease clinical severity nor to modify immunologic parameters in the CNS. These results indicate that hsp65, administered as a DNA vaccine, was not therapeutic for EAE. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Neuroimmunology
dc.sourceWeb of Science
dc.subjectExperimental autoimmune encephalomyelitis hsp65en
dc.subjectDNA vaccineen
dc.subjectCD4+CD25+Foxp3+T cellsen
dc.titleDownmodulation of peripheral MUG-specific immunity by pVAXhspe65 treatment during EAE does not reach the CNSen
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFundacao Dr Amaral Carvalho
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Microbiol & Immunol, Biosci Inst, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationFundacao Dr Amaral Carvalho, Lab Citometria Fluxo, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Dept Biochem & Immunol, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Microbiol & Immunol, Biosci Inst, BR-18618970 Sao Paulo, Brazil
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 11/07528-5
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
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