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dc.contributor.authorZanoni, Thalita B.
dc.contributor.authorPaula, Eloisa Silva de
dc.contributor.authorZocolo, Guilherme Juliao [UNESP]
dc.contributor.authorZanoni, Maria Valnice B. [UNESP]
dc.contributor.authorOliveira, Danielle Palma de
dc.date.accessioned2014-12-03T13:11:28Z
dc.date.available2014-12-03T13:11:28Z
dc.date.issued2013-10-01
dc.identifierhttp://dx.doi.org/10.1080/02772248.2014.892748
dc.identifier.citationToxicological And Environmental Chemistry. Abingdon: Taylor & Francis Ltd, v. 95, n. 9, p. 1506-1517, 2013.
dc.identifier.issn0277-2248
dc.identifier.urihttp://hdl.handle.net/11449/113182
dc.description.abstractIncubation of guanosine and Sudan III induces the formation of a stable adduct, which may be identified using a spectrophotometric technique and mass spectroscopy. The high nucleophilicity of the C-8 position and its proximity to N-7 makes the site susceptible to a nucleophilic attack, which explains the S(N)2 reaction detected between guanosine and Sudan III dye. In addition, direct interaction of Sudan III with calf thymus DNA was monitored using a simple spectrophotometric technique. The results presented indicate that a simple modification of the chemical structure of Sudan I (monoazo dye) to Sudan III (diazo dye) markedly alters reactivity towards nitrogenous DNA bases.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent1506-1517
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofToxicological and Environmental Chemistry
dc.sourceWeb of Science
dc.subjectSudan dye adductsen
dc.subjecttoxicology of azo dyesen
dc.subjectSudan III dyeen
dc.titleIdentification of Sudan III-(deoxy)-guanosine adducts formed in situ in a reaction with no catalysten
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Sao Paulo, Dept Environm Toxicol, Sch Pharmaceut Sci, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUNESP, Dept Analyt Chem, Inst Chem Araraquara, Araraquara, Brazil
dc.description.affiliationUnespUNESP, Dept Analyt Chem, Inst Chem Araraquara, Araraquara, Brazil
dc.identifier.doi10.1080/02772248.2014.892748
dc.identifier.wosWOS:000334906700006
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 08/10449-7
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.author.orcid0000-0002-2296-1393[4]
dc.relation.ispartofjcr0.972
dc.relation.ispartofsjr0,313
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