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dc.contributor.authorLopes, L. T. [UNESP]
dc.contributor.authorBiancardi, V. [UNESP]
dc.contributor.authorVieira, E. B.
dc.contributor.authorLeite-Panissi, C.
dc.contributor.authorBicego, K. C. [UNESP]
dc.contributor.authorGargaglioni, L. H. [UNESP]
dc.date.accessioned2014-12-03T13:11:30Z
dc.date.available2014-12-03T13:11:30Z
dc.date.issued2014-07-01
dc.identifierhttp://dx.doi.org/10.1111/apha.12254
dc.identifier.citationActa Physiologica. Hoboken: Wiley-blackwell, v. 211, n. 3, p. 528-537, 2014.
dc.identifier.issn1748-1708
dc.identifier.urihttp://hdl.handle.net/11449/113205
dc.description.abstractAim Although periaqueductal grey matter activation is known to elicit respiratory and cardiovascular responses, the role of this midbrain area in the compensatory responses to hypoxia is still unknown. To test the participation of the periaqueductal grey matter in cardiorespiratory and thermal responses to hypoxia in adult male Wistar rats, we performed a chemical lesion of the dorsolateral/dorsomedial or the ventrolateral/lateral periaqueductal grey matter using ibotenic acid. Methods Pulmonary ventilation, mean arterial pressure, heart rate and body temperature were measured in unanaesthetized rats during normoxic and hypoxic exposure (5, 15, 30min, 7% O2). Results An ibotenic acid lesion of the dorsolateral/dorsomedial periaqueductal grey matter caused a higher increase in pulmonary ventilation (67.1%, 1730 +/- 282.5mLkg-1min-1) compared to the Sham group (991.4 +/- 194mLkg-1min-1) after 15min in hypoxia, whereas for the ventrolateral/Lateral periaqueductal grey matter lesion, no differences were observed between groups. Mean arterial pressure, heart rate and body temperature were not affected by a dorsolateral/dorsomedial or ventrolateral/lateral periaqueductal grey matter lesion. Conclusion Middle to caudal portions of the dorsolateral/dorsomedial periaqueductal grey matter neurones modulate the hypoxic ventilatory response, exerting an inhibitory modulation during low O2 situations. In addition, the middle to caudal portions of the dorsolateral/dorsomedial or ventrolateral/lateral periaqueductal grey matter do not appear to exert a tonic role on cardiovascular or thermal parameters during normoxic and hypoxic conditions.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipINCT-Fisiologia Comparada
dc.format.extent528-537
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofActa Physiologica
dc.sourceWeb of Science
dc.subjectmidbrainen
dc.subjectperipheral chemoreflexen
dc.subjectrespirationen
dc.titleParticipation of the dorsal periaqueductal grey matter in the hypoxic ventilatory response in unanaesthetized ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationSao Paulo State Univ FCAV UNESP, Dept Anim Morphol & Physiol, Jaboticabal, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Dent Sch Ribeirao Preto, Dept Morphol Physiol & Basic Pathol, Ribeirao Preto, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ FCAV UNESP, Dept Anim Morphol & Physiol, Jaboticabal, SP, Brazil
dc.identifier.doi10.1111/apha.12254
dc.identifier.wosWOS:000337616500009
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
dc.relation.ispartofjcr5.930
dc.relation.ispartofsjr1,542
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