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dc.contributor.authorToledo, Thais Regina [UNESP]
dc.contributor.authorDejani, Naiara N. [UNESP]
dc.contributor.authorSilva Monnazzi, Luis Gustavo [UNESP]
dc.contributor.authorKossuga, Miriam H.
dc.contributor.authorBerlinck, Roberto G. S.
dc.contributor.authorSette, Lara D. [UNESP]
dc.contributor.authorMedeiros, Alexandra Ivo de [UNESP]
dc.date.accessioned2014-12-03T13:11:43Z
dc.date.available2014-12-03T13:11:43Z
dc.date.issued2014-01-01
dc.identifierhttp://dx.doi.org/10.1155/2014/767061
dc.identifier.citationMediators Of Inflammation. New York: Hindawi Publishing Corporation, 11 p., 2014.
dc.identifier.issn0962-9351
dc.identifier.urihttp://hdl.handle.net/11449/113455
dc.description.abstractVery little is known about the immunomodulatory potential of secondary metabolites isolated from marine microorganisms. In the present study, we characterized pyrenocine A, which is produced by the marine-derived fungus Penicillium paxilli Ma(G) K and possesses anti-inflammatory activity. Pyrenocine A was able to suppress, both pretreatment and posttreatment, the LPS-induced activation of macrophages via the inhibition of nitrite production and the synthesis of inflammatory cytokines and PGE2. Pyrenocine A also exhibited anti-inflammatory effects on the expression of receptors directly related to cell migration (Mac-1) as well as costimulatory molecules involved in lymphocyte activation (B7.1). Nitrite production was inhibited by pyrenocine A in macrophages stimulated with CpG but not Poly I:C, suggesting that pyrenocine A acts through the MyD88-dependent intracellular signaling pathway. Moreover, pyrenocine A is also able to inhibit the expression of genes related to NF kappa B-mediated signal transduction on macrophages stimulated by LPS. Our results indicate that pyrenocine A has promissory anti-inflammatory properties and additional experiments are necessary to confirm this finding in vivo model.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent11
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofMediators of Inflammation
dc.sourceWeb of Science
dc.titlePotent Anti-Inflammatory Activity of Pyrenocine A Isolated from the Marine-Derived Fungus Penicillium paxilli Ma(G) Ken
dc.typeArtigo
dcterms.rightsHolderHindawi Publishing Corporation
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, BR-13506900 Rio Claro, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Bioquim & Microbiol, BR-13506900 Rio Claro, SP, Brazil
dc.identifier.doi10.1155/2014/767061
dc.identifier.wosWOS:000330704700001
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2010/50190-2
dc.description.sponsorshipIdCNPq: 302097/2010-4
dc.description.sponsorshipIdFAPESP: 2008/00331-9
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt
dc.identifier.fileWOS000330704700001.pdf
unesp.author.lattes8756770929017974[7]
unesp.author.orcid0000-0001-6048-3647[7]
dc.relation.ispartofjcr3.549
dc.relation.ispartofsjr1,370
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