A magnetically drivable nanovehicle for curcumin with antioxidant capacity and MRI relaxation properties
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Data
2014-09-08
Autores
Magro, Massimiliano
Campos, Rene [UNESP]
Baratella, Davide
Lima, Giuseppina [UNESP]
Hola, Katerina
Divoky, Clemens
Stollberger, Rudolf
Malina, Ondrej
Aparicio, Claudia
Zoppellaro, Giorgio
Título da Revista
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Título de Volume
Editor
Wiley-Blackwell
Resumo
Curcumin possesses wide-ranging anti-inflammatory and anti-cancer properties and its biological activity can be linked to its potent antioxidant capacity. Superparamagnetic maghemite (gamma-Fe2O3), called surface-active maghemite nanoparticles (SAMNs) were surface-modified with curcumin molecules, due to the presence of under-coordinated Fe-III atoms on the nanoparticle surface. The so-obtained curcumin-modified SAMNs (SAMN@curcumin) had a mean size of 13 +/- 4 nm. SAMN@curcumin was characterized by transmission and scanning electron microscopy, UV/Vis, FTIR, and Mossbauer spectroscopy, X-ray powder diffraction, bulk susceptibility (SQUID), and relaxometry measurements (MRI imaging). The high negative contrast proclivity of SAMN@curcumin to act as potential contrast agent in MRI screenings was also tested. Moreover, the redox properties of bound curcumin were probed by electrochemistry. SAMN@curcumin was studied in the presence of different electroactive molecules, namely hydroquinone, NADH and ferrocyanide, to assess its redox behavior. Finally, SAMN@curcumin was electrochemically probed in the presence of hydrogen peroxide, demonstrating the stability and reactivity of bound curcumin.
Descrição
Palavras-chave
antioxidants, curcumin, electrocatalysis, magnetic nanoparticles, MRI contrast agents
Como citar
Chemistry-a European Journal. Weinheim: Wiley-v C H Verlag Gmbh, v. 20, n. 37, p. 11913-11920, 2014.