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dc.contributor.authorCandido, Caroline Damico [UNESP]
dc.contributor.authorCampos, Michel Leandro [UNESP]
dc.contributor.authorCorrea Vidigal Assumpcao, Juliana Uruguay [UNESP]
dc.contributor.authorPestana, Kelly Chrystina [UNESP]
dc.contributor.authorPadilha, Elias Carvalho [UNESP]
dc.contributor.authorCarlos, Iracilda Zeppone [UNESP]
dc.contributor.authorPeccinini, Rosangela Goncalves [UNESP]
dc.date.accessioned2015-03-18T15:52:35Z
dc.date.available2015-03-18T15:52:35Z
dc.date.issued2014-10-01
dc.identifierhttp://dx.doi.org/10.1002/jps.24106
dc.identifier.citationJournal Of Pharmaceutical Sciences. Hoboken: Wiley-blackwell, v. 103, n. 10, p. 3297-3301, 2014.
dc.identifier.issn0022-3549
dc.identifier.urihttp://hdl.handle.net/11449/116204
dc.description.abstractThe incorporation of doxorubicin (DOX) in a microemulsion (DOX-ME) has shown beneficial consequences by reducing the cardiotoxic effects of DOX. The aim of this study was to determine the distribution of DOX-ME in Ehrlich solid tumor (EST) and the heart, and compare it with that of free DOX. The distribution study was conducted with female Swiss mice with EST (n = 7 per group; 20-25 g). Animals received a single dose (10 mg/kg, i.p.) of DOX or DOX-ME 7 days after tumor inoculation. Fifteen minutes after administration, the animals were sacrificed, and the tumor and heart tissues were taken for immediate analysis by ultra-performance liquid chromatography. No difference was observed in DOX concentration in tumor tissue between DOX and DOX-ME administration. However, the most remarkable result in this study was the statistically significant reduction in DOX concentration in heart tissue of animals given DOX-ME. Mean DOX concentration in heart tissue was 0.92 +/- 0.54 ng mg(-1) for DOX-ME and 1.85 +/- 0.34 ng mg(-1) for free DOX. In conclusion, DOX-ME provides a better tissue distribution profile, with a lower drug concentration in heart tissue but still comparable tumor drug concentration, which indicates that antitumor activity would not be compromised. (c) 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:3297-3301, 2014en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent3297-3301
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal Of Pharmaceutical Sciences
dc.sourceWeb of Science
dc.subjectmicroemulsionen
dc.subjectformulationen
dc.subjectdoxorubicinen
dc.subjectEhrlich tumoren
dc.subjectliquid chromatographyen
dc.subjectUPLCen
dc.subjectdistributionen
dc.subjectpharmacokineticsen
dc.subjecttoxicologyen
dc.titleBiocompatible Microemulsion Modifies the Tissue Distribution of Doxorubicinen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationSao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Nat Act Principles & Toxicol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14801902 Araraquara, SP, Brazil
dc.identifier.doi10.1002/jps.24106
dc.identifier.wosWOS:000342661300034
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 11/11239-9
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
dc.identifier.lattes1730146818754269
dc.identifier.lattes1066743423929093
unesp.author.lattes1730146818754269
unesp.author.lattes1066743423929093
unesp.author.orcid0000-0002-2692-8101[7]
unesp.author.orcid0000-0002-0084-3468[6]
unesp.author.orcid0000-0002-7147-7637[2]
unesp.author.orcid0000-0002-3794-9389[5]
dc.relation.ispartofjcr3.075
dc.relation.ispartofsjr0,984
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