Chitosan/(ureasil-PEO hybrid) blend for drug delivery
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Data
2014-11-01
Autores
Paredes, Mayte [UNESP]
Pulcinelli, Sandra Helena [UNESP]
Peniche, Carlos
Goncalves, Vanessa [UNESP]
Santilli, Celso Valentim [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Springer
Resumo
The effect of chitosan addition on the structure and drug release properties of ureasil-polyethylene oxide (U-PEO) hybrid materials was examined. The hybrids and the blends were prepared by the sol-gel route and their structural features were characterized by infrared spectroscopy, differential scanning calorimetry, X-ray powder diffraction, and small angle X-ray scattering. The different characterization techniques revealed the formation of transparent, rubbery, flexible, water-insoluble, and low crystalline chitosan/(U-PEO hybrid) blends, which could easily dissolve pramoxine (used as a model drug). The results showed that the combined addition of chitosan and pramoxine improved the compatibility of the organic and inorganic components of the U-PEO matrix, and provided a means of tailoring the amount of drug released at steady state equilibrium.
Descrição
Palavras-chave
Sol-gel, Hybrid materials, Chitosan, Chitosan blends, Drug delivery
Como citar
Journal Of Sol-gel Science And Technology. Dordrecht: Springer, v. 72, n. 2, p. 233-238, 2014.