Spectroscopic, luminescence and in vitro biological studies of solid ketoprofen of heavier trivalent lanthanides and yttrium(III)
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Data
2014-11-01
Autores
Galico, D. A. [UNESP]
Lahoud, M. G. [UNESP]
Davolos, Marian Rosaly [UNESP]
Frem, Regina Célia Galvão [UNESP]
Fraga-Silva, T. F. C. [UNESP]
Venturini, J. [UNESP]
Arruda, M. S. P. [UNESP]
Bannach, G. [UNESP]
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Elsevier B.V.
Resumo
Solid-state compounds of the general formulae [ML3] (M = Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, Y; L = ketoprofen) were synthesized and characterized using infrared, diffuse reflectance and luminescence spectroscopies. IR data suggested that the carboxylate group in ketoprofen is coordinated to the metals as a bidentate ligand. The triplet state energy level was determined using the Gd3+ complex, which exhibited a ketoprofen blue luminescence when excited in the UV region. The compound containing Tb3+ ion was sensitized by the ligand and emitted in the green region of the visible spectrum. On the other hand, for the analogous species containing the dysprosium ion, a competition for luminescence between the Dy3+ and the ligand levels was observed. Finally, Tm3+ complex exhibits only ligand luminescence. These optical behaviors are discussed based on rare earth energy diagrams. In addition, the compounds were evaluated for their anti-inflammatory activities. All the compounds showed a higher production of H2O2 and IL-10 than the ketoprofen, suggesting that the compounds exhibited an immunomodulatory effect and this opens up new perspectives for immunotherapeutic approaches. (C) 2014 Elsevier Inc. All rights reserved.
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Ketoprofen, Lanthanide complexes, Infrared spectroscopy, Carboxylate coordination, Lanthanide luminescence, Biological studies
Como citar
Journal Of Inorganic Biochemistry. New York: Elsevier Science Inc, v. 140, p. 160-166, 2014.