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dc.contributor.authorDela Coleta, Karina [UNESP]
dc.contributor.authorSilveira, Liciana Vaz de Arruda [UNESP]
dc.contributor.authorLima, Daniela F. [UNESP]
dc.contributor.authorRampinelli, Eva A. [UNESP]
dc.contributor.authorGodoy, Ilda de [UNESP]
dc.contributor.authorGodoy, Irma de [UNESP]
dc.date.accessioned2014-05-20T13:35:03Z
dc.date.available2014-05-20T13:35:03Z
dc.date.issued2008-04-01
dc.identifierhttp://dx.doi.org/10.1016/j.rmed.2007.12.003
dc.identifier.citationRespiratory Medicine. London: W B Saunders Co Ltd, v. 102, n. 4, p. 512-518, 2008.
dc.identifier.issn0954-6111
dc.identifier.urihttp://hdl.handle.net/11449/12023
dc.description.abstractLittle evidence-based guidance is available to aid clinicians in determining short-term prognoses in very severe COPD patients. Therefore, the present study was designed to provide a prospective assessment (1) of the mortality rates and (2) whether the baseline measurements may be determinants of 1-year mortality in hypoxemic COPD patients receiving long-term oxygen therapy (LTOT).Seventy-eight clinically stable patients with advanced COPD treated using LTOT were enrolled in a prospective cohort study. Outcome variable: first-year mortality. Baseline measurements: categorical variables: age (<60 or >= 60 years); gender; body mass index (<20 or >= 20 kg/m(2)); fat-free mass (FFM) index (<16 [men] and <15kg/m(2) [women]; baseline dyspnea index (BDI) (<= 3 or >3); and corticosteroid use. Continuous variables: smoking history; lung function; FFM; fat mass; hemoglobin; hematocrit; arterial blood gases; forearm muscle strength; St. George's Respiratory Questionnaire (SGRQ); and comorbidity score. By the end of 1-year of follow-up, 12 patients (15.4%) had died. Kaplan-Meier curves showed that BDI <= 3 was the only variable associated with higher mortality. Cox proportional hazards analysis revealed that tower PaO2 and SPO2, higher PaCO2 and SGRQ scores were associated with reduced survival. In the multivariate analysis, BDI remained predictive of mortality (hazard ratio [HR], 0.50; 95% confidence interval [CI], 0.31-0.81), as did PaO2 (HR, 0.49; 95% CI, 0.26-0.95). These data suggest that readily available parameters as dyspnea intensity and hypoxemia severity may be useful in predicting first-year survival rates in advanced COPD patients receiving LTOT (C) 2007 Elsevier Ltd. All rights reserved.en
dc.format.extent512-518
dc.language.isoeng
dc.publisherW B Saunders Co Ltd
dc.relation.ispartofRespiratory Medicine
dc.sourceWeb of Science
dc.subjectpulmonary diseaseen
dc.subjectchronic obstructive/mortalityen
dc.subjectdyspneaen
dc.subjectoxygen inhalationen
dc.subjecttherapy/utilizationen
dc.titlePredictors of first-year survival in patients with advanced COPD treated using long-term oxygen therapyen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderW B Saunders Co Ltd
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Med Sch, Div Pulm,Dept Internal Med, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Biosci Inst, Dept Biostat, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Nursing, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Med Sch, Div Pulm,Dept Internal Med, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Biosci Inst, Dept Biostat, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Botucatu Med Sch, Dept Nursing, BR-18618000 Botucatu, SP, Brazil
dc.identifier.doi10.1016/j.rmed.2007.12.003
dc.identifier.wosWOS:000254302300005
dc.rights.accessRightsAcesso aberto
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.fileWOS000254302300005.pdf
dc.identifier.lattes5079454858778041
dc.identifier.lattes7805298466001457
unesp.author.lattes5079454858778041
unesp.author.lattes7805298466001457
unesp.author.orcid0000-0001-8931-5495[2]
unesp.author.orcid0000-0002-6588-5626[6]
dc.relation.ispartofjcr3.230
dc.relation.ispartofsjr1,472
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