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dc.contributor.authorDe Luca, Ana Karina Cristiuma [UNESP]
dc.contributor.authorNakazawa, Cristiane Yoshie [UNESP]
dc.contributor.authorAzevedo, Beatriz Camargo [UNESP]
dc.contributor.authorRudge, Marilza Vieira Cunha [UNESP]
dc.contributor.authorCosta, Roberto Antonio de Araújo [UNESP]
dc.contributor.authorCalderon, Iracema de Mattos Paranhos [UNESP]
dc.date.accessioned2014-05-20T13:35:16Z
dc.date.available2014-05-20T13:35:16Z
dc.date.issued2009-01-01
dc.identifierhttp://dx.doi.org/10.1080/00016340903118018
dc.identifier.citationActa Obstetricia Et Gynecologica Scandinavica. Oslo: Taylor & Francis As, v. 88, n. 9, p. 1036-1040, 2009.
dc.identifier.issn0001-6349
dc.identifier.urihttp://hdl.handle.net/11449/12120
dc.description.abstractObjective. To evaluate the influence of glycemic control on fetal lung maturity in pregnancies affected by diabetes or mild hyperglycemia. Design. Cross-sectional study. Setting. Level III maternity center. Population. A total of 187 pregnant women were submitted to routine amniocentesis for the assessment of fetal lung maturity up to 72 hours before delivery. Methods. Fetal lung maturity thresholds were: Clements-positive at a dilution of 0.5; OD(650) nm >= 0.15; and lamellar body count (LBC) >= 32,000/mu l. The relation of test results with adequate (<= 6.7 mmol/l) or poor (> 6.7 mmol/l) glycemic mean (GM) at term and at preterm was evaluated. Main outcome measure. Delay in fetal lung maturity when glycemic control was poor. Results. Glycemic control was adequate in 146 (78.1%) women. Clements maturity rates were higher at term (91.9%) than at preterm (64.7%) when GM <= 6.7 mmol/l (p < 0.001), but not when control was inadequate. LBC median was higher at term (99.0; 62.0-154.0) than at preterm (66.5; 40.5-108.25) (p = 0.009) when GM <= 6.7 mmol/l, while GM > 6.7 mmol/l did not lead to any difference between these rates at term or preterm. When glycemic control was adequate, OD(650) nm medians at term and at preterm were similar. However, when GM > 6.7 mmol/l, OD(650) nm median at term (0.29; 0.22-0.40) was higher than that observed at preterm (0.15; 0.12-0.18) (p < 0.001). Conclusions. Our results suggest that in term pregnancies routine amniocentesis for the assessment of fetal lung maturity should be abandoned. In preterm pregnancies, or when glycemic control is inadequate it is recommended.en
dc.format.extent1036-1040
dc.language.isoeng
dc.publisherTaylor & Francis As
dc.relation.ispartofActa Obstetricia et Gynecologica Scandinavica
dc.sourceWeb of Science
dc.subjectFetal lung maturityen
dc.subjectdiabetes in pregnancyen
dc.subjectamniocentesisen
dc.titleInfluence of glycemic control on fetal lung maturity in gestations affected by diabetes or mild hyperglycemiaen
dc.typeArtigo
dcterms.licensehttp://poj.peeters-leuven.be/content.php?url=CMS.php§ion=individual_subscribers
dcterms.rightsHolderTaylor & Francis As
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationSão Paulo State Univ UNESP, Dept Pediat, Botucatu Med Sch, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationSão Paulo State Univ UNESP, Dept Gynecol & Obstet, Botucatu Med Sch, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Pediat, Botucatu Med Sch, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Gynecol & Obstet, Botucatu Med Sch, BR-18618970 Botucatu, SP, Brazil
dc.identifier.doi10.1080/00016340903118018
dc.identifier.wosWOS:000269094900015
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.lattes6758680388835078
dc.identifier.lattes0679387622604743
dc.identifier.lattes1884059321499759
dc.identifier.orcid0000-0002-9227-832X
dc.identifier.orcid0000-0003-4074-252X
unesp.author.lattes6758680388835078
unesp.author.lattes0679387622604743
unesp.author.lattes1884059321499759[5]
unesp.author.orcid0000-0003-4761-4336[6]
unesp.author.orcid0000-0002-9227-832X[4]
unesp.author.orcid0000-0003-4074-252X[5]
dc.relation.ispartofjcr2.649
dc.relation.ispartofsjr1,283
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