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dc.contributor.advisorMarcondes, Mary [UNESP]
dc.contributor.authorCardinot, Cinthya Brillante [UNESP]
dc.date.accessioned2015-04-09T12:28:12Z
dc.date.available2015-04-09T12:28:12Z
dc.date.issued2013-01-08
dc.identifier.citationCARDINOT, Cinthya Brillante. Identificação de DNA de Leishmania sp. no encéfalo de cães com Leishmaniose visceral. 2013. 48 f. Dissertação (mestrado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária, 2013.
dc.identifier.urihttp://hdl.handle.net/11449/121940
dc.description.abstractThere are few reports of neurological disorders in dogs with visceral leishmaniasis, with or without the participation of other opportunistic agents. The aim fo the present study was to investigate, by Real Time PCR, the presence of Leishmania sp. in the brain of dogs naturally affected by visceral leishmaniasis (VL). We evaluated 24 dogs with VL, of whom two were asymptomatic and two had also neurological symptoms. DNA was amplified in the brain of 23/24 (95.8%) dogs. The parasite load ranged from 2-16964 amastigotes/mL with a median of 116 parasites/mL and mean and standard deviation of 1166 ± 3546 parasites/mL. The average number of parasites in dogs with VL with neurological disorders, in dogs without neurological alterations and in asymptomatic dogs were, respectively, 2010, 1119 and 772 parasites/mL. These results demonstrate that the parasite has the ability to penetrate into the nervous system and should contribute to the development of neurological lesionsen
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent48 f.
dc.language.isopor
dc.publisherUniversidade Estadual Paulista (UNESP)
dc.sourceAleph
dc.subjectLeishmaniapt
dc.subjectReação em cadeia de polimerasept
dc.subjectSistema nervoso centralpt
dc.subjectCãopt
dc.subjectDNApt
dc.subjectManifestações neurológicas de doençaspt
dc.subjectReal time PCRpt
dc.titleIdentificação de DNA de Leishmania sp. no encéfalo de cães com Leishmaniose visceralpt
dc.typeDissertação de mestrado
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.rights.accessRightsAcesso aberto
dc.description.sponsorshipIdFAPESP: 2011/2227-0
unesp.graduateProgramCiência Animal - FMVApt
unesp.knowledgeAreaFisiopatologia médica e cirúrgicapt
unesp.researchAreaFisiopatologia médica e cirurgica de pequenos animaispt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária, Araçatubapt
dc.identifier.aleph000814188
dc.identifier.file000814188.pdf
dc.identifier.capes33004021075P8
dc.identifier.lattes1817946671090010
unesp.author.lattes1817946671090010
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