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dc.contributor.authorPeraçoli, Maria Terezinha Serrão [UNESP]
dc.contributor.authorBannwart-Castro, Camila F. [UNESP]
dc.contributor.authorCristofalo, Renata [UNESP]
dc.contributor.authorBorges, Vera Therezinha Medeiros [UNESP]
dc.contributor.authorAraujo Costa, Roberto A. [UNESP]
dc.contributor.authorWitkin, Steven Sol [UNESP]
dc.contributor.authorPeraçoli, José Carlos [UNESP]
dc.date.accessioned2014-05-20T13:35:29Z
dc.date.available2014-05-20T13:35:29Z
dc.date.issued2011-12-01
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0897.2011.01016.x
dc.identifier.citationAmerican Journal of Reproductive Immunology. Hoboken: Wiley-blackwell, v. 66, n. 6, p. 460-467, 2011.
dc.identifier.issn1046-7408
dc.identifier.urihttp://hdl.handle.net/11449/12212
dc.description.abstractProblemTo evaluate associations between hyperuricemia and increases in production of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-alpha) in pre-eclamptic pregnancies.Method of studyThis study investigated serum uric acid levels, monocyte production of TNF-alpha, superoxide anion (O-2(-)) and hydrogen peroxide (H2O2), as well as superoxide dismutase (SOD) and catalase (CAT) activities in erythrocytes from 30 women with pre-eclampsia (PE) compared with 30 normotensive (NT) pregnant women in the last trimester of pregnancy.ResultsSerum uric acid levels (6.1 versus 2.8 mg/dL) as well as endogenous O-2(-) (2.2 versus 1.6 nm), H2O2 (1.8 versus 1.4 nm) and TNF-alpha (91.6 versus 40.4 pg/mL) released from monocytes were significantly higher in the pre-eclamptic group than in the NT group (P < 0.05). SOD activity in erythrocytes was also significantly elevated in the PE group (5969.2 versus 4834.7 U/g Hb). No significant difference between groups was observed in relation to CAT activity.ConclusionsElevated serum uric acid levels are correlated with higher O-2(-) and TNF-alpha production by monocytes in women with PE. This may contribute to the enhanced oxidative and inflammatory state characteristic of this disorder.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent460-467
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofAmerican Journal of Reproductive Immunology
dc.sourceWeb of Science
dc.subjectO-2(-)en
dc.subjectpre-eclampsiaen
dc.subjectSODen
dc.subjectTNF-alphaen
dc.subjecturic aciden
dc.titleIncreased Reactive Oxygen Species and Tumor Necrosis Factor-Alpha Production by Monocytes are Associated with Elevated Levels of Uric Acid in Pre-Eclamptic Womenen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionCornell Univ
dc.description.affiliationUNESP São Paulo State Univ, Dept Microbiol & Immunol, Inst Biociences, São Paulo, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Dept Obstet & Ginecol, Botucatu Med Sch, São Paulo, Brazil
dc.description.affiliationCornell Univ, Div Immunol & Infect Dis, Weill Med Coll, Dept Obstet & Gynecol, New York, NY 10021 USA
dc.description.affiliationUnespUNESP São Paulo State Univ, Dept Microbiol & Immunol, Inst Biociences, São Paulo, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Dept Obstet & Ginecol, Botucatu Med Sch, São Paulo, Brazil
dc.identifier.doi10.1111/j.1600-0897.2011.01016.x
dc.identifier.wosWOS:000296896300003
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 06/07095-3
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.lattes8499437381595614
dc.identifier.lattes6486557387397806
unesp.author.lattes8499437381595614
unesp.author.lattes6486557387397806
unesp.author.orcid0000-0002-0936-9512[1]
dc.relation.ispartofjcr2.745
dc.relation.ispartofsjr1,210
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