Desenvolvimento e caracterização de nanocápsulas de poli(l-lactídeo) contendo benzocaína
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Data
2010
Autores
Melo, Nathalie Ferreira Silva de [UNESP]
Grillo, Renato [UNESP]
Fraceto, Leonardo Fernandes [UNESP]
Dias Filho, Newton Luiz [UNESP]
Paula, Eneida de
Araújo, Daniele Ribeiro de
Rosa, André Henrique [UNESP]
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Resumo
In this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of –38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment.
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nanocapsulas, benzocaína, caracterização físico-química
Como citar
Química Nova, v. 33, n. 1, p. 65-69, 2010.