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dc.contributor.authorNogueira, E.
dc.contributor.authorRosa, GJM
dc.contributor.authorVassilieff, V. S.
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 61, n. 2, p. 119-126, 1998.
dc.description.abstractTo investigate the ability of hexanic ethanolic fraction of Rubus brasiliensis Martius (Roseceae), to induce anxiolytic effect and also the possible involvement of the GABA(A)-benzodiazepine receptor complex, male Wistar rats and Swiss mice behaviour were tested in the elevated plus maze (EPM). All the doses of the extract, 50, 100 and 150 mg/kg, administered per gavage (vo), 30 min before the behavioural evaluation, induced an anxiolytic effect expressed by: increased number of entries in and time spent in the open arms and percentage of open arm entries: and decreased number of entries and time spent in the closed arms. The treatment of mice with flumazenil (Ro 15-1788), 0.5, 1.0 and 1.5 mg/kg, i.p., 15-min before the administration of hexanic fraction, 100 mg/kg, vo, blocked the hexanic fraction-induced anxiolytic effect. The LD50 for the hexanic fraction was 1512 mg/kg. In conclusion, it was shown that the hexanic fraction of R. brasiliensis induced an anxiolytic effect in rats and mice. This effect can be attributed to a liposoluble principle with low toxicity which may be acting as an agonist on GABA(A)-benzodiazepine receptor complex. (C) 1998 Elsevier B.V. Ireland Ltd. All rights reserved.en
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.sourceWeb of Science
dc.subjectRubus brasiliensispt
dc.subjectanxiolytic effectpt
dc.subjectelevated plus mazept
dc.subjectbenzodiazepine receptorpt
dc.titleInvolvement of GABA(A)-benzodiazepine receptor in the anxiolytic effect induced by hexanic fraction of Rubus brasiliensisen
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUNESP, Biosci Inst, Dept Pharmacol, Neuropharmacol Lab, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Biosci Inst, Dept Biostat, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Biosci Inst, Dept Pharmacol, Neuropharmacol Lab, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Biosci Inst, Dept Biostat, BR-18618000 Botucatu, SP, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt[2]
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