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dc.contributor.authorSilva, Regildo Márcio Gonçalves da [UNESP]
dc.contributor.authorRodrigues, Débora Thaís Miranda [UNESP]
dc.contributor.authorValadares, Fillipi [UNESP]
dc.contributor.authorOliva Neto, Pedro de [UNESP]
dc.contributor.authorSantos, Lucinéia dos [UNESP]
dc.contributor.authorSilva, Luciana Pereira [UNESP]
dc.date.accessioned2015-05-15T13:30:30Z
dc.date.available2015-05-15T13:30:30Z
dc.date.issued2012
dc.identifier.citationJournal of Medicinal Plant Research, v. 6, n. 24, p. 4142-4148, 2012.
dc.identifier.issn1996-0875
dc.identifier.urihttp://hdl.handle.net/11449/123612
dc.description.abstractThis study aimed to investigate the antitumor and cytotoxicity activities of Kielmeyera coriacea and Pyrostegia venusta extracts. Therefore, the hydroalcoholic extracts of P. venusta flowers and K. coriacea leaves were prepared. The extracts were evaporated and the dry extracts were diluted at concentrations of 1.0, 0.1, 0.01 and 0.001 mg/ml for carrying out the bioassays. Artemia salina eggs were incubated in saline solution at 28°C for 24 h. The larvae were treated with different extracts concentrations and the mortality was evaluated after 24 and 48 h. Five discs of potato were placed in Petri dishes and 50 μl of inoculum of Agrobacterium tumefaciens were added to it at 28°C for 24 h incubation. So, 50 μl of the extracts in different concentrations were added. Positive and negative controls were made. The P. venusta and K. coriacea extracts did not show statistically significant acute toxicity. K. coriacea extract showed (mean% of tumor ± standard deviation) 15.30 ± 3.24, 6.34 ± 3.82, 7.57 ± 2.92 and 5.77 ± 2.85 and P. venusta showed 25.82 ± 5.15, 38.40 ± 8.28, 15.75 ± 4.44 and 13.38 ± 7.92, with their concentrations for the antitumor bioassay, and the positive control showed 25.80 ± 6.14. According to the obtained results it was established that the K. coriacea and P. venusta extracts showed antitumor activity but did not show significant cytotoxic activity in A. salina test.en
dc.format.extent4142-4148
dc.language.isoeng
dc.relation.ispartofJournal of Medicinal Plant Research
dc.sourceCurrículo Lattes
dc.subjectKielmeyera coriaceaen
dc.subjectPyrostegia venustaen
dc.subjectAgrobacterium tumefaciensen
dc.subjectantitumor activityen
dc.subjectcytotoxic activityen
dc.titleAntitumor and cytotoxic activity of Kielmeyera coriacea mart. Zucc. and Pyrostegia venusta (ker-gawl.) Miers extractsen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências e Letras de Assis, Assis, Avenida Dom Antonio, 2100, Vila Universitária, CEP 19806-900, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências e Letras de Assis, Assis, Avenida Dom Antonio, 2100, Vila Universitária, CEP 19806-900, SP, Brasil
dc.identifier.doi10.5897/JMPR12.691
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências e Letras, Assispt
dc.identifier.lattes5285324361162578
dc.identifier.lattes8207280726883591
unesp.author.lattes5285324361162578
unesp.author.lattes8207280726883591
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