Now showing items 1-10 of 44
Antineoplastic mechanism of gemcitabine on tumor cells with different TP53/p53 subtypes
(Gemcitabine: Pharmacology, Clinical Uses and Potential Side Effects, 2014-07-01) [Capítulo de livro]
The aim of this chapter is to provide updated information on the mechanisms by which gemcitabine acts on tumor cells with different TP53 gene backgrounds. Currently, the genetic backgrounds of tumors and patients have been ...
Genotoxicity of corrosion eluates obtained from orthodontic brackets in vitro
(American Journal of Orthodontics and Dentofacial Orthopedics, 2011-04-01) [Artigo]
Introduction: The purpose of this study was to evaluate whether corrosion eluates obtained from commercially available orthodontic brackets are able to induce genetic damage in vitro. Material and Methods: Genotoxicity was ...
Citral and eugenol modulate DNA damage and pro-inflammatory mediator genes in murine peritoneal macrophages
(Molecular Biology Reports, 2014-11-01) [Artigo]
Citral and eugenol have been broadly studied because of their anti-inflammatory, antioxidant and antiparasitic potentials. In this study, the effects of citral (25, 50 and 100 mu g/mL) and eugenol (0.31, 0.62, 1.24 and ...
Evaluation of Oxidative DNA Damage, Lipid Peroxidation and Antioxidant Status in Patients Undergoing Surgery with Sevoflurane Anesthesia
(FASEB Journal, 2013-04-01) [Resumo]
STORAGE RESULTS IN LOSS of THE ANTIGENOTOXIC PROPERTIES of LENTINULA EDODES (SHIITAKE MUSHROOM) and DEVELOPMENT of IN VIVO GENOTOXICITY
(Journal of Food Biochemistry, 2010-02-01) [Artigo]
In this study, we have investigated the stability of the antigenotoxic properties of dried of Lentinula edodes (Berk.) Singer mushroom powder stored at room and at -20C. Mice were pretreated by gavage for 15 consecutive ...
DNA damage in patients who underwent minimally invasive surgery under inhalation or intravenous anesthesia
(Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 2011-12-24) [Artigo]
Recent studies have demonstrated the genotoxicity of anesthetics in patients who have undergone surgery and in personnel who are occupationally exposed to anesthetics. However, these findings are controversial. Herein, we ...
Gene polymorphisms and increased DNA damage in morbidly obese women
(Mutation Research-fundamental And Molecular Mechanisms Of Mutagenesis, 2015-06-01) [Artigo]
Obesity is characterized by increased adipose tissue mass resulting from a chronic imbalance between energy intake and expenditure. Furthermore, there is a clearly defined relationship among fat mass expansion, chronic ...
Genetic Instability Persists in Non-Neoplastic Urothelial Cells from Patients with a History of Urothelial Cell Carcinoma
(PLOS ONE, 2014-01-22) [Artigo]
Bladder cancer is one of the most common genitourinary neoplasms in industrialized countries. Multifocality and high recurrence rates are prominent clinical features of this disease and contribute to its high morbidity. ...
Cell cycle kinetics, apoptosis rates, DNA damage and TP53 gene expression in bladder cancer cells treated with allyl isothiocyanate (mustard essential oil)
(Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 2014-04-01) [Artigo]
Allyl isothiocyanate (AITC) is present in plants of the cruciferous family and is abundant in mustard seed. Due to its high bioavailability in urine after ingestion, AITC has been considered a promising antineoplastic agent ...
Either Intravenous or Inhaled Anesthetic for Elective Otorhinological Surgery Does Not Induce Oxidative Stress
(FASEB Journal, 2012-04-01) [Resumo]