Now showing items 1-10 of 137
Antineoplastic mechanism of gemcitabine on tumor cells with different TP53/p53 subtypes
(Gemcitabine: Pharmacology, Clinical Uses and Potential Side Effects, 2014-07-01) [Capítulo de livro]
The aim of this chapter is to provide updated information on the mechanisms by which gemcitabine acts on tumor cells with different TP53 gene backgrounds. Currently, the genetic backgrounds of tumors and patients have been ...
Oxidative DNA damage in patients with gastritis and gastric cancer infected by Helicobacter pylori
(Helicobacter, 2005-10-01) [Resumo]
Viable human buccal mucosa cells do not yield typical nucleoids: Impacts on the single-cell gel electrophoresis/comet assay
(Environmental and Molecular Mutagenesis, 2006-03-01) [Artigo]
Buccal mucosa (BM) cells have been used in human biomonitoring studies for detecting DNA adducts and chromosomal damage in an epithelial cell population. In the present study, we have investigated if human BM cells are ...
Ex vivo biocompatibility tests of regular and white forms of mineral trioxide aggregate
(International Endodontic Journal, 2006-01-01) [Artigo]
Aim: To examine the genotoxicity and cytotoxicity of regular and white mineral trioxide aggregate (MTA) ex vivo by the single-cell gel (comet) assay and trypan blue exclusion test, respectively. Methodology: Aliquots of 1 ...
Single-cell gel (comet) assay detects primary DNA damage in nonneoplastic urothelial cells of smokers and ex-smokers
(Cancer Epidemiology Biomarkers & Prevention, 2001-09-01) [Artigo]
A protocol for DNA damage assessment by the single-cell gel (SCG)/comet assay in human urinary bladder washing cells was established. Modifications of the standard alkaline protocol included an increase to 2% of sodium ...
Study on the mutagenicity and antimutagenicity of a natural food colour (annatto) in mouse bone marrow cells
(Food and Chemical Toxicology, 2003-02-01) [Artigo]
Most manufactured foods contain chemicals added as a deliberate part of the manufacturing process. The aims of the present study were to evaluate the mutagenicity and antimutagenicity of annatto, a natural pigment extracted ...
Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci
(Cancer Science, 2003-02-01) [Artigo]
The modifying potential of crude extracts of the mushroom Agaricus blazei Murrill (Himematsutake) on the development and growth of glutathione S-transferase placental form (GST-P)-positive liver foci (liver preneoplastic ...
Absence of carcinogenic and anticarcinogenic effects of annatto in the rat liver medium-term assay
(Food and Chemical Toxicology, 2004-10-01) [Artigo]
Annatto (Bixa orellana L.) is a natural food colorant extensively used in many processed foods, especially dairy products. The lower cost of production and the low toxicity, make annatto a very attractive and convenient ...
Aberrant crypt foci and colon cancer: comparison between a short- and medium-term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats
(Brazilian Journal of Medical and Biological Research, 2002-03-01) [Artigo]
Aberrant crypt foci (ACF) in the colon of carcinogen-treated rodents are considered to be the earliest hallmark of colon carcinogenesis. In the present study the relationship between a short-term (4 weeks) and medium-term ...
Genotoxicity of corrosion eluates obtained from orthodontic brackets in vitro
(American Journal of Orthodontics and Dentofacial Orthopedics, 2011-04-01) [Artigo]
Introduction: The purpose of this study was to evaluate whether corrosion eluates obtained from commercially available orthodontic brackets are able to induce genetic damage in vitro. Material and Methods: Genotoxicity was ...