Now showing items 1-10 of 104
Worldwide HLA-E nucleotide and haplotype variability reveals a conserved gene for coding and 3 ' untranslated regions
(Tissue Antigens, 2014-02-01) [Artigo]
The human leukocyte antigen-E (HLA-E) locus is a human major histocompatibility complex (MHC) gene associated with immune-modulation and suppression of the immune response by the interaction with specific natural killer ...
Potential endocrinedisruptor activity of drinking water samples
(Endocrine Disruptors, 2015) [Artigo]
Conventional water treatment plants (WTP) do not completely remove contaminants with endocrine activity which may then be present in drinking water (DW). The potential for endocrine disruption of 2 DW samples collected in ...
Effects of diuron on toxicological and hematological parameters and lymphohematopoietic organs in a rat chemical hepatocarcinogenesis model
(Annual Review of Biomedical Sciences, 2005) [Artigo]
Effects of swim training on liver carcinogenesis in male Wistar rats fed a low-fat or high-fat diet
(Applied Physiology Nutrition and Metabolism = Physiologie Appliquee Nutrition Et Metabolisme, 2012-12-01) [Artigo]
The present study aimed to investigate the beneficial effects of swim training on the promotion-progression stages of rat liver carcinogenesis. Male Wistar rats were submitted to chemically induced liver carcinogenesis and ...
Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework
(Critical Reviews In Toxicology, 2014-05-01) [Artigo]
Diuron, a high volume substituted urea herbicide, induced high incidences of urinary bladder carcinomas and low incidences of kidney pelvis papillomas and carcinomas in rats exposed to high doses (2500 ppm) in a 2-year ...
beta-Glucan extracted from the medicinal mushroom Agaricus blazei prevents the genotoxic effects of benzo[a]pyrene in the human hepatoma cell line HepG2
(Archives of Toxicology, 2009-01-01) [Artigo]
The mushroom Agaricus blazei is studied for its nutraceutical potential and as a medicinal supplement. The aim of the present study was to investigate the chemoprotective effect of beta-glucan extracted from the mushroom ...
Balancing immunity and tolerance: genetic footprint of natural selection in the transcriptional regulatory region of HLA-G
(Genes And Immunity, 2015-01-01) [Artigo]
Human leukocyte antigen-G (HLA-G) has well-recognized immunosuppressive properties modulating the activity of many immune system cells, and polymorphisms observed at the HLA-G 5'upstream regulatory region (5'URR) may ...
Insights into HLA-G genetics provided by worldwide haplotype diversity
(Frontiers In Immunology, 2014-10-06) [Artigo]
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I genes, located within the major histocompatibility complex (MHC). HLA-G has been the target of most recent research regarding the function ...
HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells
(Journal Of Leukocyte Biology, 2014-10-01) [Artigo]
Tumors are complex structures containing different types of cells and molecules. The importance of the tumor microenvironment in tumor progression, growth, and maintenance is well-established. However, tumor effects are ...
Ocular melanoma and mammary mucinous carcinoma in an African lion
(BMC Veterinary Research, 2012-09-25) [Artigo]
Background: Reports of neoplasms in Panthera species are increasing, but they are still an uncommon cause of disease and death in captive wild felids. The presence of two or more primary tumor in large felids is rarely ...