Now showing items 1-10 of 55
Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT1A-receptors and reduces cholesterol after repeated oral treatment
(BMC Complementary and Alternative Medicine, 2013-02-23) [Artigo]
Background: The current treatments for anxiety disorders and depression have multiple adverse effects in addition to a delayed onset of action, which has prompted efforts to find new substances with potential activity in ...
Macrophage activity and histopathology of the lymphohematopoietic organs in male Wistar rats orally exposed to single or mixed pesticides
(Journal of Environmental Science and Health - Part B: Pesticides, Food Contaminants, and Agricultural Wastes, 2013-07-01) [Artigo]
The noxious effects of low or effective dose exposure to single or mixed pesticides on macrophage activity and the lymphohematopoietic organs were investigated. Male Wistar rats were orally exposed to dichlorvos, dicofol, ...
Dose-response of diuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] in the urothelial mucosa of Wistar rats
(Toxicology, 2013-08-20) [Artigo]
Diuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] is a herbicide that induced urothelial tumors in the urinary bladder of Wistar rats fed 2500. ppm during a long-term study. The currently suggested non-genotoxic mode of ...
Cytokine profile of Ehrlich ascites tumor treated with Bothrops jararaca venom
(Mediators of Inflammation, 2002-08-01) [Artigo]
WE previously demonstrated that Bothrops jararaca venom (BjV) has an antitumor effect on Ehrlich ascites tumor (EAT) cells and induces an increase of polymorphonuclear leukocytes in early stages of tumor growth. It has ...
Previous contact with Strongyloides venezuelensis contributed to prevent insulitis in MLD-STZ diabetes
(Experimental Parasitology, 2013-06-01) [Artigo]
Epidemiological and experimental studies support the idea that helminth infections can induce a protective effect against the development of autoimmune and allergic diseases. In this study we characterized the immune ...
Diet-induced obesity impairs AKT signalling in the retina and causes retinal degeneration
(Cell Biochemistry and Function, 2013-01-01) [Artigo]
Retinopathy, a common complication of diabetes, is characterized by an unbalanced production of nitric oxide (NO), a process regulated by nitric oxide synthase (NOS). We hypothesized that retinopathy might stem from changes ...
Intestinal malakoplakia associated with paracoccidiodomycosis: A new association
(Histopathology, 1997-02-21) [Artigo]
Brazilian experience with the medium-term multi-organ bioassay: Scientific and regulatory developments
(Asian Pacific Journal of Cancer Prevention, 2010-08-25) [Trabalho apresentado em evento]
In 1996 the Brazilian Institute for the Environment (IBAMA) officially adopted a variation of the multiorgan initiation-promotion DMBDD bioassay as a valid source of evidence of the carcinogenic potential of pesticides. ...
Pulmonary paracoccidioidomycosis in immunized mice
(Mycopathologia, 1992-07-01) [Artigo]
Paracoccidioidomycosis was induced in immunized (IM) and non-immunized (NI) mice. The histopathology, the number of fungi in the lungs, the cellular (footpad test - FPT and macrophage inhibition factor assay - MIF) and ...
Frequent p53 mutations and occasional loss of chromosome 4 in invasive bladder carcinoma induced by N-butyl-N-(4-hydroxybutil)nitrosamine in B6D2F1 mice
(Molecular Carcinogenesis, 1998-03-16) [Artigo]
B6D2F1 mice (45/group) were treated with N-butyl-N-(4- hydroxybutyl)nitrosamine (BBN) or uracil as follows: Group 1 received 0.05% BBN in drinking water for the entire experiment, Group 2 received 5 mg of BBN by gastric ...