Now showing items 1-6 of 6
DNA damage and nitric oxide synthesis in experimentally infected Balb/c mice with Trypanosoma cruzi
(Experimental Parasitology, 2007-07-01) [Artigo]
This study aimed to evaluate whether experimental Chagas disease in acute phase under benznidazole therapy can cause DNA damage in peripheral blood, liver, heart, and spleen cells or induce nitric oxide synthesis in spleen ...
MS222 does not induce primary DNA damage in fish
(Aquaculture International, 2007-04-01) [Artigo]
The genotoxicity of the anaesthetic MS222 (tricaine) was analysed in fish under both in vivo and in vitro conditions. Based on results of the single cell gel/Comet assay, MS222 had no direct genotoxic effect on the ...
Paracoccidioidomycosis: No genetic damage in human peripheral blood cells of patients assessed by single-cell gel (comet) assay
(Revista da Sociedade Brasileira de Medicina Tropical, 2007-07-01) [Artigo]
Paracoccidioidomycosis is a systemic fungal infection caused by Paracoccidioides brasiliensis. As infectious diseases can cause DNA damage, the authors aimed at analyzing DNA breakage in peripheral blood cells of patients ...
Influence of endogenous and synthetic female sex hormones on human blood cells in vitro studied with comet assay
(Toxicology in Vitro, 2007-08-01) [Artigo]
The comet assay has been conducted with numerous cell lines to assess in vitro genotoxicity. In order to use the comet assay as part of an in vitro test for evaluating genotoxicity, however, there are cell-specific factors ...
Lack of effect of prior treatment with fluoride on genotoxicity of two chemical agents in vitro
(Caries Research, 2007-01-01) [Artigo]
The goal of this study was to investigate the ability of fluoride to modulate the genotoxic effects induced by the oxidative agent hydrogen peroxide (H2O2) and the alkylating agent methyl methanesulfonate (MMS) in vitro ...
Lack of genotoxicity induced by endogenous and synthetic female sex hormones in peripheral blood cells detected by alkaline Comet assay
(Environmental and Molecular Mutagenesis, 2007-06-01) [Artigo]
The etiology of hormone-induced cancers has been considered to be a combination of genotoxic and epigenetic events. Currently, the Comet assay is widely used for detecting genotoxicity because it is relatively simple, ...