Now showing items 1-10 of 16
Citrus aurantium L. essential oil exhibits anxiolytic-like activity mediated by 5-HT1A-receptors and reduces cholesterol after repeated oral treatment
(BMC Complementary and Alternative Medicine, 2013-02-23) [Artigo]
Background: The current treatments for anxiety disorders and depression have multiple adverse effects in addition to a delayed onset of action, which has prompted efforts to find new substances with potential activity in ...
Dose-response of diuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] in the urothelial mucosa of Wistar rats
(Toxicology, 2013-08-20) [Artigo]
Diuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] is a herbicide that induced urothelial tumors in the urinary bladder of Wistar rats fed 2500. ppm during a long-term study. The currently suggested non-genotoxic mode of ...
Diet-induced obesity impairs AKT signalling in the retina and causes retinal degeneration
(Cell Biochemistry and Function, 2013-01-01) [Artigo]
Retinopathy, a common complication of diabetes, is characterized by an unbalanced production of nitric oxide (NO), a process regulated by nitric oxide synthase (NOS). We hypothesized that retinopathy might stem from changes ...
Lack of protective effects of zinc gluconate against rat colon carcinogenesis
(Nutrition and Cancer, 2013-05-01) [Artigo]
Zinc has been proposed as a promising chemopreventive candidate against colon cancer. However, few studies on the potential beneficial effects of this trace element on cancer chemoprevention are available. The present study ...
Lack of association between HLA-E polymorphisms and transitional cell carcinoma of the bladder
(Tissue Antigens, 2013-09-01) [Carta]
Treatment of adriamycin-induced nephropathy with erythropoietin and G-CSF
(Journal of Nephrology, 2013-05-01) [Artigo]
Background: Granulocyte colony-stimulating factor (G-CSF) and Erythropoietin (EPO) are known to stimulate the growth and differentiation of progenitor cells to prevent acute renal injury. This study aimed to assess the use ...
Morphologic and biomechanical changes of thoracic and abdominal aorta in a rat model of cigarette smoke exposure
(Annals of Vascular Surgery, 2013-08-01) [Artigo]
Background: Smoking is the most relevant environmental factor that affects the development of aortic aneurysm. Smokers have elevated levels of elastase activity in the arterial wall, which leads to weakening of the aorta. ...
Dietary, anthropometric, and biochemical determinants of uric acid in free-living adults
(Nutrition Journal, 2013-01-16) [Artigo]
Background: High plasma uric acid (UA) is a prerequisite for gout and is also associated with the metabolic syndrome and its components and consequently risk factors for cardiovascular diseases. Hence, the management of ...
A Comparative Genotoxicity Study of a Supraphysiological Dose of Triiodothyronine (T3) in Obese Rats Subjected to Either Calorie-Restricted Diet or Hyperthyroidism
(PLOS ONE, 2013-02-28) [Artigo]
This study was designed to determine the genotoxicity of a supraphysiological dose of triiodothyronine (T3) in both obese and calorie-restricted obese animals. Fifty male Wistar rats were randomly assigned to one of the ...
DNA repair gene polymorphism is associated with the genetic basis of atherosclerotic coronary artery disease
(Cardiovascular Pathology, 2011-01-01) [Artigo]
Background: Atherosclerotic coronary artery disease (CAD) is a multifactorial process that appears to be caused by the interaction of environmental risk factors with multiple predisposing genes. It is nowadays accepted ...