Now showing items 11-20 of 577
Sewage sludge does not induce genotoxicity and carcinogenesis
(Genetics and Molecular Biology, 2012-01-01) [Artigo]
Through a series of experiments, the genotoxic/mutagenic and carcinogenic potential of sewage sludge was assessed. Male Wistar rats were randomly assigned to four groups: Group 1 - negative control; Group 2 - liver ...
Compounds used to produce cloned animals are genotoxic and mutagenic in mammalian assays in vitro and in vivo
(Brazilian Journal of Medical and Biological Research, 2014-04-01) [Artigo]
The compounds 6-dimethylaminopurine and cycloheximide promote the successful production of cloned mammals and have been used in the development of embryos produced by somatic cell nuclear transfer. This study investigated ...
Role of selective cyclo-oxygenase-2 inhibitor celecoxib in canine osteosarcoma cell culture
(Open Journal of Pathology, 2013) [Artigo]
Background: Experimental studies have shown that cyclo-oxygenase-2 (Cox2) is related to the development and progression of tumors, since this enzyme is induced and expressed by cells such as macrophages, osteoblasts, ...
Oxidative stress and inflammatory mediators contribute to endothelial dysfunction in high-fat diet-induced obesity in mice
(Journal of Hypertension, 2010-10-01) [Artigo]
Objective We investigated the effects of high-fat diet-induced obesity on vascular proinflammatory factors and oxidative stress on endothelium-dependent relaxation of the aorta.Methods Female Swiss mice were submitted to ...
Subchronic Toxicity Evaluation of a Treated Urban Sewage Sludge
(Journal of Toxicology and Environmental Health: Part A Current Issues, 2010-01-01) [Artigo]
Disposal of tons of sludge produced daily by sewage treatment plants in large cities is a serious problem. Because recycling and application in agriculture have been proposed, the Brazilian National Environmental Council ...
A nonsynonymous mutation at HLA-E defines the new E*01:06 allele in Brazilian individuals
(Tissue Antigens, 2013-09-01) [Artigo]
We report a novel nonclassical class I HLA-E*01:06 allele observed in Brazilian individuals.
Triiodothyronine indirectly increases amphiregulin gene expression levels via estrogen receptor activation
(FASEB Journal, 2013-04-01) [Resumo]
Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework
(Critical Reviews In Toxicology, 2014-05-01) [Artigo]
Diuron, a high volume substituted urea herbicide, induced high incidences of urinary bladder carcinomas and low incidences of kidney pelvis papillomas and carcinomas in rats exposed to high doses (2500 ppm) in a 2-year ...
Inflammatory response to polymicrobial infection in human fetal membranes
(American Journal of Obstetrics and Gynecology, 2014-01-01) [Resumo]