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Viable human buccal mucosa cells do not yield typical nucleoids: Impacts on the single-cell gel electrophoresis/comet assay
(Environmental and Molecular Mutagenesis, 2006-03-01) [Artigo]
Buccal mucosa (BM) cells have been used in human biomonitoring studies for detecting DNA adducts and chromosomal damage in an epithelial cell population. In the present study, we have investigated if human BM cells are ...
Ex vivo biocompatibility tests of regular and white forms of mineral trioxide aggregate
(International Endodontic Journal, 2006-01-01) [Artigo]
Aim: To examine the genotoxicity and cytotoxicity of regular and white mineral trioxide aggregate (MTA) ex vivo by the single-cell gel (comet) assay and trypan blue exclusion test, respectively. Methodology: Aliquots of 1 ...
Single-cell gel (comet) assay detects primary DNA damage in nonneoplastic urothelial cells of smokers and ex-smokers
(Cancer Epidemiology Biomarkers & Prevention, 2001-09-01) [Artigo]
A protocol for DNA damage assessment by the single-cell gel (SCG)/comet assay in human urinary bladder washing cells was established. Modifications of the standard alkaline protocol included an increase to 2% of sodium ...
Study on the mutagenicity and antimutagenicity of a natural food colour (annatto) in mouse bone marrow cells
(Food and Chemical Toxicology, 2003-02-01) [Artigo]
Most manufactured foods contain chemicals added as a deliberate part of the manufacturing process. The aims of the present study were to evaluate the mutagenicity and antimutagenicity of annatto, a natural pigment extracted ...
Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci
(Cancer Science, 2003-02-01) [Artigo]
The modifying potential of crude extracts of the mushroom Agaricus blazei Murrill (Himematsutake) on the development and growth of glutathione S-transferase placental form (GST-P)-positive liver foci (liver preneoplastic ...
Aberrant crypt foci and colon cancer: comparison between a short- and medium-term bioassay for colon carcinogenesis using dimethylhydrazine in Wistar rats
(Brazilian Journal of Medical and Biological Research, 2002-03-01) [Artigo]
Aberrant crypt foci (ACF) in the colon of carcinogen-treated rodents are considered to be the earliest hallmark of colon carcinogenesis. In the present study the relationship between a short-term (4 weeks) and medium-term ...
Absence of DNA damage in multiple organs after oral exposure to fluoride in Wistar rats
(Bulletin of Environmental Contamination and Toxicology, 2006-11-01) [Artigo]
In vitro cytotoxic and non-genotoxic effects of gutta-percha solvents on mouse lymphoma cells by single cell gel (comet) assay
(Brazilian Dental Journal, 2006-12-01) [Artigo]
Chloroform and eucalyptol are widely used in clinical dentistry as gutta-percha solvents. However, these compounds may represent a hazard to human health, especially by causing injury to genetic apparatus and/or inducing ...
Imbalance of Tumor Suppression Genes Expression Following Rat Tongue Carcinogenesis Induced by 4-Nitroquinoline 1-Oxide
(In Vivo, 2009-11-01) [Artigo]
This study was undertaken to investigate, by immunohistochemistry, the expression of some tumor suppressor genes such asp 16, p21 and Retinoblastoma (Rb) during 4-Nitroquinoline I-oxide induced rat tongue carcinogenesis. ...
Lack of genotoxicity of formocresol, paramonochlorophenol, and calcium hydroxide on mammalian cells by comet assay
(Journal of Endodontics, 2004-08-01) [Artigo]
Formocresol, paramonochlorophenol, and calcium hydroxide are widely used in dentistry because of their antibacterial activities in root canal disinfection. However, the results of genotoxicity studies using these materials ...