RSS 1.0Artigos - Patologia - FMB
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Epstein-Barr Virus microRNAs in the pathogenesis of human cancers
; ; ; Oliveira, Deilson Elgui de
(Cancer Letters, 2020) [Artigo]
The Epstein-Barr Virus (EBV) is a gamma-herpesvirus involved with a variety of human cancers, notably the endemic Burkitt lymphoma and nasopharyngeal carcinoma. In 2004, EBV was described as one the first known human ... -
Acute aortic wall injury caused by aortic cross-clamping: Morphological and biomechanical study of the aorta in a swine model of three aortic surgery approaches
Prata, Marcela Polachini; Jaldin, Rodrigo Gibin ; Lourenção, Pedro Luiz Toledo de Arruda ; Sobreira, Marcone Lima ; Yoshida, Ricardo de Alvarenga ; Terra, Simone Antunes ; Viero, Rosa Marlene ; Yoshida, Winston Bonetti (Jornal Vascular Brasileiro, 2020) [Artigo]
Background: Aortic cross-clamping and balloon occlusion of the aorta could lead to damage to the aorta wall. Objective: The aim of this study was to investigate changes to the aorta wall related to the method used to ... -
Hydroethanolic Extract of Solanum paniculatum L. Fruits Modulates ROS and Cytokine in Human Cell Lines
Ferraz, Ana Paula C. R.; ; Garcia, Jéssica L. ; Costa, Mariane R. ; Francisqueti-Ferron, Fabiane V. ; Ferron, Artur J. T. ; Silva, Carol Cristina V. De A. ; Corrente, José Eduardo ; Manfio, Vanessa M. ; Namba, Vickeline et al. (Oxidative Medicine and Cellular Longevity, 2020) [Artigo]
Solanum paniculatum L. or popularly known as jurubeba is an herbal medicinal plant. A few studies have investigated its biological effects; however, research aimed at elucidating the redox balance effects from its fruits ... -
Genetic Alterations in Patients with Two Clinical Phenotypes of Multiple Sclerosis
Feliciano, Luciana Maria; ; ; ; Salvadori, Daisy Maria Fávero (Journal of Molecular Neuroscience, 2020) [Artigo]
The etiology of multiple sclerosis (MS) is still not known, but the interaction of genetic, immunological, and environmental factors seem to be involved. This study aimed to investigate genetic alterations and the vitamin ... -
Topical buparvaquone nano-enabled hydrogels for cutaneous leishmaniasis
; ; ; ; ; ; ; Felipe Domingues Passero, Luiz; Serrano, Dolores R. (International Journal of Pharmaceutics, 2020) [Artigo]
Leishmaniasis is a neglected disease presenting cutaneous, mucosal and visceral forms and affecting an estimated 12 million mostly low-income people. Treatment of cutaneous leishmaniasis (CL) is recommended to expedite ... -
Oral hairy leukoplakia in a child using a corticosteroid nasal spray
Costa, Fernanda Herrera; Costa, Victor ; León, Jorge Esquiche ; ; ; Kaminagakura, Estela (Pediatric Dermatology, 2020) [Artigo]
We report a case of atypical oral hairy leukoplakia (OHL) in a 9-year-old immunocompetent girl treated with fluticasone propionate nasal spray for allergic rhinitis. The OHL in childhood is uncommon and should be included ... -
Botryomycosis in patient with pituitary microadenome: A case report
; ; D. Passero, Luiz Felipe (Dermatologic Therapy, 2020) [Carta]
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Successful treatment of chromoblastomycosis caused by Fonsecaea pedrosoi using imiquimod
; ; Passero, Luiz Felipe Domingues (Journal of Dermatology, 2020) [Artigo]
Chromoblastomycosis (CBM) is a fungal infection caused by fungi belonging to the order Chaetothyriales, and caused mainly by Fonsecaea pedrosoi. The classic treatment, based on itraconazole and/or terbinafine as well as ... -
Bilateral canine seminoma with ocular metastasis: Histochemical and immunohistochemical characterization
; ; Silva, Germana A.; Sanctis, Paula ; Belluci, Renata S. ; Brandao, Claudia Valeria ; Rocha, Noeme S. (Brazilian Journal of Veterinary Pathology, 2020) [Artigo]
A 10-year old male dog was examined due to a buphthalmia in the left eye and a nodule in the two testicles. Due to the limited resources of the owner and loss of visual acuity of the patient, the enucleation and castration ... -
The combination of coffee compounds attenuates early fibrosis-associated hepatocarcinogenesis in mice: involvement of miRNA profile modulation
Romualdo, Guilherme Ribeiro; Prata, Gabriel Bacil ; ; ; ; ; ; ; Barbisan, Luís Fernando (Journal of Nutritional Biochemistry, 2020) [Artigo]
Aberrant microRNA expression implicates on hepatocellular carcinoma (HCC) development. Conversely, coffee consumption reduces by ~40% the risk for fibrosis/cirrhosis and HCC, while decaffeinated coffee does not. It is ... -
Capsaicin lacks tumor-promoting effects during colon carcinogenesis in a rat model induced by 1,2-dimethylhydrazine
Caetano, Brunno Felipe Ramos; Tablas, Mariana Baptista ; Ignoti, Marcela Gonçalves ; de Moura, Nelci Antunes ; Romualdo, Guilherme Ribeiro ; Barbisan, Luís Fernando ; Rodrigues, Maria Aparecida Marchesan (Environmental Science and Pollution Research, 2020) [Artigo]
Capsaicin (CPS, 8-methyl-N-vanillyl-trans-6-nonenamide), a pungent alkaloid from chili peppers, has contradictory effects in both experimental and human carcinogenesis. Thus, we evaluated the modifying effects of chronic ... -
Inflammation, but not infection, induces EMT in human amnion epithelial cells
de Castro Silva, Mariana; ; ; ; da Silva, Márcia Guimarães ; (Reproduction (Cambridge, England), 2020) [Artigo]
A non-reversible state of epithelial to mesenchymal transition (EMT) at term accumulates proinflammatory mesenchymal cells and predisposes fetal membrane to weakening prior to delivery at term. We investigated the induction ... -
Oxidative stress monitoring in in vitro and in vivo models
Lima, Thania Rios Rossi; Sales, Bianca Camargo Penteado ; Pereira, Lilian Cristina (Role of Oxidative Stress in Pathophysiology of Diseases, 2020) [Capítulo de livro]
In aerobic organisms, cellular respiration is an essential process that is divided into several steps. The third and last step is called oxidative phosphorylation, which occurs in the mitochondria, specifically in the inner ... -
Characterization of the vaginal microbiome in women of reproductive age from 5 Regions in Brazil
Marconi, Camila; ; ; ; ; ; ; Parada, Cristina M G L. ; ; et al. (Sexually Transmitted Diseases, 2020) [Artigo]
Background Composition of the vaginal microbiome is strongly related to a woman's reproductive health and risk of sexually transmitted infections. Ethnoracial, behavioral, and environmental factors can influence microbiome. ... -
Adjustments in β-adrenergic signaling contribute to the amelioration of cardiac dysfunction by exercise training in supravalvular aortic stenosis
De Souza, Sérgio Luiz Borges; Mota, Gustavo Augusto Ferreira ; Da Silvaa Paula Grippa Sant'Ana, Vitor Loureiro ; Vileigas, Danielle Fernandes ; De Campos, Dijon Henrique Salomé ; Padovani, Carlos Roberto ; Rodrigues, Maria Aparecida Marchesan ; ; ; Bazan, Silmeia Garcia Zanati et al. (Cellular Physiology and Biochemistry, 2020) [Artigo]
Background/Aims: Aortic stenosis-induced chronic pressure overload leads to cardiac dysfunction and congestive heart failure. The pathophysiological mechanisms of the myocardial impairment are multifactorial and include ... -
Anti-PSMA monoclonal antibody increases the toxicity of paclitaxel carried by carbon nanotubes
Comparetti, Edson José; Romagnoli, Graziela Gorete ; Gorgulho, Carolina Mendonça ; Pedrosa, Valber de Albuquerque ; Kaneno, Ramon (Materials Science and Engineering C, 2020) [Artigo]
Multiple-wall carbon nanotubes (CNTs) were functionalized with polyethyleneimine in order to incorporate paclitaxel (PTX), the first line chemotherapeutic agent for prostate cancer. These particles were then covered with ... -
Protective Effects of Dietary Capsaicin on the Initiation Step of a Two-Stage Hepatocarcinogenesis Rat Model
Sarmiento-Machado, Luis Manuel; Romualdo, Guilherme Ribeiro ; Zapaterini, Joyce Regina ; Tablas, Mariana Baptista ; Fernandes, Ana Angélica Henrique ; ; Barbisan, Luís Fernando (Nutrition and Cancer, 2020) [Artigo]
Capsaicin (CPS), an ingredient of Capsicum plants, has anti-inflammatory, antioxidant and antitumoral properties. The mechanisms of CPS on hepatocarcinogenesis preclinical bioassays are not described. Thus, the protective ... -
Nanoparticle-mediated oxidative stress monitoring
Lima, Thania Rios Rossi; ; Pereira, Lilian Cristina (Nanotechnology in Modern Animal Biotechnology: Concepts and Applications, 2019) [Capítulo de livro]
Free radicals are unstable atoms or molecules that can be not only generated under physiologic conditions but also induced by many exogenous compounds. They interact with many molecular and cellular targets and may cause ... -
Increased angiotensin II from adipose tissue modulates myocardial collagen I and III in obese rats
da Silva-Bertani, Danielle Cristina Tomaz; Vileigas, Danielle Fernandes ; Mota, Gustavo Augusto Ferreira ; de Souza, Sérgio Luiz Borges ; Sant'Ana, Paula Grippa ; Freire, Paula Paccielli ; de Tomasi, Loreta Casquel ; Corrêa, Camila Renata ; Padovani, Carlos Roberto ; et al. (Life Sciences, 2020) [Artigo]
It has been described that the cardiac dysfunction in the obesity model is because of collagen imbalance and that angiotensin II (Ang II) contributes to myocardial fibrosis. However, it remains undefined if changes in ... -
Early molecular events associated with liver and colon sub-acute responses to 1,2-dimethylhydrazine: Potential implications on preneoplastic and neoplastic lesion development
Ramos Caetano, Brunno Felipe; Baptista Tablas, Mariana ; Ribeiro Romualdo, Guilherme ; Marchesan Rodrigues, Maria Aparecida ; Barbisan, Luís Fernando (Toxicology Letters, 2020) [Artigo]
This study unveiled the early cellular and molecular events induced by 1,2-dimethylhydrazine (DMH) in the colon and liver and their implications on pre- and neoplastic lesion burden in a late timepoint. Male Wistar rats ...