Now showing items 1-10 of 140
Medium-term tongue carcinogenesis assays: A comparative study between 4-nitroquinoline 1-oxide (4NQO)-induced rat and dimethylbenzanthracene (DMBA)-induced hamster carcinogenesis
(Journal of Experimental Animal Science, 2006-12-12) [Artigo]
The most used animal models in oral cancer research are the hamster treated by dimethylbenzanthracene (DMBA), and the rat treated by 4-nitroquinoline 1-oxide (4NQO). The purpose of this study was to compare the DMBA-induced ...
DNA damage in lymphocytes and buccal mucosa cells of children with malignant tumours undergoing chemotherapy
(Clinical and Experimental Medicine, 2008-06-01) [Artigo]
The aim of the present study was to evaluate DNA damage (micronucleus) in cytokinesis-blocked lymphocytes and exfoliated buccal mucosa cells from children with malignant tumours and under chemotherapy. Micronucleated cells ...
The role of p53 protein and TP53 gene during rat oral carcinogenesis induced by 4NQO
(Oral Oncology, 2009-07-01) [Artigo]
Oxidative DNA damage in patients with gastritis and gastric cancer infected by Helicobacter pylori
(Helicobacter, 2005-10-01) [Resumo]
DNA methylation patterns in bladder cancer and washing cell sediments: a perspective for tumor recurrence detection
(BMC Cancer, 2008-08-14) [Artigo]
Background: Epigenetic alterations are a hallmark of human cancer. In this study, we aimed to investigate whether aberrant DNA methylation of cancer-associated genes is related to urinary bladder cancer recurrence.Methods: ...
Toxicogenomic late effects of antineoplastic therapies for lymphomas
(Environmental and Molecular Mutagenesis, 2011-10-01) [Resumo]
Brazilian natural dietary components (annatto, propolis and mushrooms) protecting against mutation and cancer
(Human & Experimental Toxicology, 2006-05-01) [Artigo]
Considering the high number of new cancer cases in Brazil (approximately 470 000 cases in 2005) and the remarkable differences in the incidence of this disease around the world, the development of chemopreventive strategies ...
Lymphoproliferative response and T lymphocyte subsets in a medium-term multi-organ bioassay for carcinogenesis in Wistar rats
(Cancer Letters, 2000-06-30) [Artigo]
The lymphoproliferative response and T lymphocyte subsets were evaluated at different stages of carcinogenesis in male Wistar, rats sequentially initiated with N-diethylnitrosamine (DEN), N-butyl-N-4(hydroxybutyl)nitrosamine ...
The HUman MicroNucleus project on eXfoLiated buccal cells (HUMNXL): The role of life-style, host factors, occupational exposures, health status, and assay protocol
(Mutation Research-reviews In Mutation Research, 2011-11-01) [Artigo]
The human buccal micronucleus cytome assay (BMCyt) is one of the most widely used techniques to measure genetic damage in human population studies. Reducing protocol variability, assessing the role of confounders, and ...
Cigarette smoke affects apoptosis in rat tongue mucosa: Role of bcl-2 gene family
(Journal of Molecular Histology, 2005-10-01) [Artigo]
While it has been clearly demonstrated that smoking is the most significant exogenous factor involved in oral carcinogenesis, little is known about the global molecular and cellular changes that occur prior to the appearance ...