Now showing items 1-10 of 98
Effectiveness of a 10-wk Lifestyle Modification Program in Reducing Hypertension in Brazilian Free-Living Adults
(Faseb Journal, 2017-04-01) [Resumo]
Loss of 5 '-Methylthioadenosine Phosphorylase (MTAP) is Frequent in High-Grade Gliomas; Nevertheless, it is Not Associated with Higher Tumor Aggressiveness
(Cells, 2020-02-01) [Artigo]
The 5'-methylthioadenosine phosphorylase (MTAP) gene is located in the chromosomal region 9p21. MTAP deletion is a frequent event in a wide variety of human cancers; however, its biological role in tumorigenesis remains ...
Protective effects of beta-glucan extracted from barley against benzo[a]pyrene-induced DNA damage in hepatic cell HepG2
(Experimental and Toxicologic Pathology, 2009-01-01) [Artigo]
The aim of the present study was to assess the genotoxic and antigenotoxic effect of beta-glucan (BG) extracted from barley. The genotoxicity of BG was tested in the single-cell gel electrophoresis assays (SCGE)/HepG2 test ...
Reappraisal of immunohistochemical profiling of special histological types of breast carcinomas: a study of 121 cases of eight different subtypes
(Journal of Clinical Pathology, 2012-12-01) [Artigo]
Histological special types (HST) account for about 25% of breast cancers, and correspond to at least 17 pathological entities. However, their molecular characteristics remain to be determined. The purpose of the present ...
Diuron-Induced Rat Bladder Epithelial Cytotoxicity
(Toxicological Sciences, 2012-12-01) [Artigo]
Diuron, a substituted urea herbicide, is carcinogenic to the rat urinary bladder at high dietary levels (2500 ppm). To further elucidate the mode of action, this study aimed to determine the time course and sequence of ...
Polymorphic Sites at the 3 ' Untranslated Region of the HLA-G Gene Are Associated with Differential hla-g Soluble Levels in the Brazilian and French Population
(PLOS ONE, 2013-10-25) [Artigo]
HLA-G molecule has well-recognized tolerogenic properties, and the encoding gene shows lower frequency of polymorphism at the coding region but higher variability at regulatory 5' and 3' untranslated (3' UTR) regions. At ...
Cell-free antigens from precocious Paracoccidioides brasiliensis culture induce a typical delayed-type hypersensitivity reaction
(Journal of Venomous Animals and Toxins Including Tropical Diseases, 2011-01-01) [Artigo]
Cell-free antigens (CFAg) derived from Paracoccidioides brasiliensis have typically been used in immunodiffusion reactions for serodiagnosis or therapeutic follow-up of paracoccidioidomycosis patients. Thus, we investigated ...
Evaluation of the antigenotoxicity of polysaccharides and beta-glucans from Agaricus blazei, a model study with the single cell gel electrophoresis/Hep G2 assay
(Journal of Food Composition and Analysis, 2009-11-01) [Artigo]
The mushroom Agaricus blazei (Agaricus brasiliensis) has been drawing attention because of its medicinal properties. Among its isolated compounds, special consideration is given to beta-glucans, which are cell wall ...
Metalloproteinases 2 and-9 activity during promotion and progression stages of rat liver carcinogenesis
(Journal of Molecular Histology, 2009-02-01) [Artigo]
Activity of metalloproteinases 2 and 9 (MMP-2 and 9) during promotion and progression of rat liver carcinogenesis was investigated in a modified resistant hepatocyte model. Development of preneoplastic liver lesions positive ...
High concentrations of waste anesthetic gases induce genetic damage and inflammation in physicians exposed for three years: A cross-sectional study
(Indoor Air, 2020-05-01) [Artigo]
This cross-sectional study analyzed the impact of occupational waste anesthetic gases on genetic material, oxidative stress, and inflammation status in young physicians exposed to inhalational anesthetics at the end of ...