Now showing items 1-6 of 6
Citral and eugenol modulate DNA damage and pro-inflammatory mediator genes in murine peritoneal macrophages
(Molecular Biology Reports, 2014-11-01) [Artigo]
Citral and eugenol have been broadly studied because of their anti-inflammatory, antioxidant and antiparasitic potentials. In this study, the effects of citral (25, 50 and 100 mu g/mL) and eugenol (0.31, 0.62, 1.24 and ...
DNA methylation patterns in bladder cancer and washing cell sediments: a perspective for tumor recurrence detection
(BMC Cancer, 2008-08-14) [Artigo]
Background: Epigenetic alterations are a hallmark of human cancer. In this study, we aimed to investigate whether aberrant DNA methylation of cancer-associated genes is related to urinary bladder cancer recurrence.Methods: ...
Cholesterol reduction and lack of genotoxic or toxic effects in mice after repeated 21-day oral intake of lemongrass (Cymbopogon citratus) essential oil
(Food and Chemical Toxicology, 2011-09-01) [Artigo]
Cymbopogon citratus (lemongrass) is currently used in traditional folk medicine. Although this species presents widespread use, there are no scientific data on its efficacy or safety after repeated treatments. Therefore, ...
Effects of lycopene, synbiotic and their association on early biomarkers of rat colon carcinogenesis
(Food and Chemical Toxicology, 2010-03-01) [Artigo]
This study evaluated whether a synergy exists for the combined treatment with lycopene and synbiotic on early biomarkers; of colon carcinogenesis. Male Wistar rats received a diet containing 300 mg/kg of lycopene and/or ...
Genotoxicity, cytotoxicity and gene expression in patients undergoing elective surgery under isoflurane anaesthesia
(Mutagenesis, 2011-05-01) [Artigo]
There are numerous studies reporting on the effects of inhalation anaesthesia in cells of exposed individuals but not much is known about the ability of isoflurane (ISF) to induce oxidative DNA damage. However, surgery is ...
Protective effects of lemongrass (Cymbopogon citratus STAPF) essential oil on DNA damage and carcinogenesis in female Balb/C mice
(Journal of Applied Toxicology, 2011-08-01) [Artigo]
This study investigated the protective effect of oral treatment with lemongrass (Cymbopogon citratus STAPF) essential oil (LGEO) on leukocyte DNA damage induced by N-methyl-N-nitrosurea (MNU). Also, the anticarcinogenic ...