Biocompatibility in vitro tests of mineral trioxide aggregate and regular and white Portland cements
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Data
2005-08-01
Autores
Ribeiro, D. A.
Duarte, MAH
Matsumoto, M. A.
Marques, MEA
Salvadori, Daisy Maria Favero [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Lippincott Williams & Wilkins
Resumo
Mineral trioxide aggregate (MTA) and Portland cement are being used in dentistry as root end-filling materials. However, biocompatibility data concerning genotoxicity and cytotoxicity are needed for complete risk assessment of these compounds. In the present study, genotoxic and cytotoxic effects of MTA and Portland cements were evaluated in vitro using the alkaline single cell gel (comet) assay and trypan blue exclusion test, respectively, on mouse lymphoma cells. The results demonstrated that the single cell gel (comet) assay failed to detect DNA damage after a treatment of cells by MTA and Portland cements for concentrations up to 1000 mu g/ml. Similarly, results showed that none of the compounds tested were cytotoxic. Taken together, these results seem to indicate that MTA and Portland cements are not genotoxins and do not induce cellular death.
Descrição
Palavras-chave
mineral trioxide aggregate, Portland cement, comet assay, genotoxicity
Como citar
Journal of Endodontics. Philadelphia: Lippincott Williams & Wilkins, v. 31, n. 8, p. 605-607, 2005.