Parecoxib reduces renal injury in an ischemia/reperfusion model in rats

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Data

2015-04-01

Autores

Calistro Neto, José Pedro [UNESP]
Torres, Rômulo da Costa [UNESP]
Gonçalves, Giovanna Maria [UNESP]
Silva, Leopoldo Muniz da [UNESP]
Domingues, Maria Aparecida Custódio [UNESP]
Módolo, Norma Sueli Pinheiro [UNESP]
Barros, Guilherme Antonio Moreira de [UNESP]

Título da Revista

ISSN da Revista

Título de Volume

Editor

Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia

Resumo

To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS: Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups. RESULTS: The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups. CONCLUSION: Parecoxib resulted in renal protection in this experimental model.

Descrição

Palavras-chave

Parecoxib, Ischemia, Reperfusion, Kidney, Rats

Como citar

Acta Cirurgica Brasileira, v. 30, n. 4, p. 270-276, 2015.