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dc.contributor.advisorSilva, Tereza Cristina Cardoso [UNESP]
dc.contributor.authorNovais, Juliana Bueno de [UNESP]
dc.date.accessioned2015-10-06T13:03:17Z
dc.date.available2015-10-06T13:03:17Z
dc.date.issued2014-01-22
dc.identifier.citationNOVAIS, Juliana Bueno de. Apoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5. 2014. 37 f. , 2014.
dc.identifier.urihttp://hdl.handle.net/11449/128098
dc.description.abstractBovine Herpesvirus type 5 (BoHV-5) and bovine herpesvirus type 1 (BoHV-1), members of Herpesviridae family, Alphaherpesvirinae subfamily; may replicate in different tissues such as nervous, glandular, lymphoid and parenchymal organs and are able to remain in a latent state, lodged in nerve ganglia. In Brazil clinical cases of BoHV - 5 encephalitis are the second leading cause of death due to encephalitis with determined etiology, supplanted only by rabies, while the BoHV-1 is present in an endemic form in the national herd, being responsible for a variety of clinical signs as rhinotracheitis, abortion, conjunctivitis, vulvovaginitis and balanoposthitis. It is expected that a viral agent, to infect a cell, activate the pathways of programmed cell death process, however there are reports that the gene related to latency (RL) of Herpesvirus is able to inhibit cell apoptosis, protecting the infected cell during latency through unknown mechanisms. Therefore, this study demonstrated the capacity of BoHV-5 and BoHV-1 to manipulate mitochondrial metabolism of the infected cell, interfering with intrinsic pathway of apoptosisen
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent37 f.
dc.language.isopor
dc.publisherUniversidade Estadual Paulista (UNESP)
dc.sourceAleph
dc.subjectVirus do herpes em animaispt
dc.subjectMorte celularpt
dc.subjectBovinopt
dc.subjectBovino - Infecçõespt
dc.subjectApoptosept
dc.subjectAlphaherpesvirinaept
dc.titleApoptose relacionada à infecção in vitro por herpesvírus bovinos tipo 1 e 5pt
dc.typeDissertação de mestrado
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.rights.accessRightsAcesso aberto
unesp.graduateProgramCiência Animal - FMVApt
unesp.knowledgeAreaMedicina Veterinária Preventiva e Produção Animalpt
unesp.researchAreaEpidemiologia, etiopatogenia, diagnóstico e controle das enfermidades dos animaispt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária, Araçatubapt
dc.identifier.aleph000848970
dc.identifier.filehttp://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/16-09-2015/000848970.pdf
dc.identifier.capes33004021075P8
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