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dc.contributor.authorRibeiro, D. A.
dc.contributor.authorMarques, MEA
dc.contributor.authorde Assis, G. F.
dc.contributor.authorAnzai, A.
dc.contributor.authorPoleti, M. L.
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.date.accessioned2014-05-20T13:37:05Z
dc.date.available2014-05-20T13:37:05Z
dc.date.issued2004-01-01
dc.identifierhttp://dx.doi.org/10.1159/000080590
dc.identifier.citationCaries Research. Basel: Karger, v. 38, n. 6, p. 576-579, 2004.
dc.identifier.issn0008-6568
dc.identifier.urihttp://hdl.handle.net/11449/12809
dc.description.abstractFluoride has been widely used in dentistry because it is an effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing injury on the genetic apparatus. Genotoxicity tests form an important part of cancer research and risk assessment of potential carcinogens. In the current study, the potential DNA damage associated with exposure to fluoride was assessed by the single cell gel ( comet) assay in peripheral blood, oral mucosa and brain cells in vivo. Male Wistar rats were exposed to sodium fluoride (NaF) at a 0, 7 and 100 ppm dose for drinking water during 6 weeks. The results pointed out that NaF did not contribute to the DNA damage in all cellular types evaluated as depicted by the mean tail moment and tail intensity. These findings are clinically important since they represent an important contribution to the correct evaluation of the potential health risk associated with dental agents exposure. Copyright (C) 2004 S. Karger AG, Basel.en
dc.format.extent576-579
dc.language.isoeng
dc.publisherKarger
dc.relation.ispartofCaries Research
dc.sourceWeb of Science
dc.subjectbrainpt
dc.subjectcomet assaypt
dc.subjectgenotoxicitypt
dc.subjectoral mucosa cellspt
dc.subjectsodium fluoridept
dc.titleNo relationship between subchronic fluoride intake and DNA damage in Wistar ratsen
dc.typeArtigo
dcterms.licensehttp://www.karger.com/Services/RightsPermissions
dcterms.rightsHolderKarger
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med Botucatu, Dept Patol, Nucleo Avaliacao Toxicogenet & Cancerigena, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUSP, Fac Odontol Bauru, Dept Ciências Biol, Histol Lab, Bauru, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Med Botucatu, Dept Patol, Nucleo Avaliacao Toxicogenet & Cancerigena, BR-18618000 Botucatu, SP, Brazil
dc.identifier.doi10.1159/000080590
dc.identifier.wosWOS:000224897200012
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.lattes5051118752980903
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[6]
dc.relation.ispartofjcr2.188
dc.relation.ispartofsjr1,108
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