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dc.contributor.authorFonseca-Alves, Carlos Eduardo [UNESP]
dc.contributor.authorKobayashi, Priscila Emiko [UNESP]
dc.contributor.authorRivera-Calderon, Luis Gabriel [UNESP]
dc.contributor.authorLaufer-Amorim, Renee [UNESP]
dc.identifier.citationResearch In Veterinary Science. Oxford: Elsevier Sci Ltd, v. 100, p. 176-181, 2015.
dc.description.abstractThe epithelial mesenchymal transition (EMT) is a fundamental event responsible for the invasiveness and metastasis of epithelial tumours. The EMT has been described in many human cancers, but there are few reports of this phenomenon in veterinary oncology. Due to the importance of this process, the current study evaluated mesenchymal and epithelial marker protein expression in prostate lesions from dogs. Our results indicate both a loss of E-cadherin and translocation of P-catenin from the membrane to the cytoplasm and nucleus in the tumour group. Vimentin expression in the tumour group was higher than in normal tissue. All of the metastases were positive for prostate-specific antigen, pan-cytokeratin and E-cadherin, although fewer positive cells were present than in the primary tumours. The immunohistochemical results showed a loss of epithelial markers and a gain of a mesenchymal marker among metastatic cells, suggesting that the EMT occurs during the metastatic process of canine prostate carcinoma. (C) 2015 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.publisherElsevier B.V.
dc.relation.ispartofResearch In Veterinary Science
dc.sourceWeb of Science
dc.subjectProstate canceren
dc.subjectEpithelial-mesenchymal crosstalken
dc.titleEvidence of epithelial-mesenchymal transition in canine prostate cancer metastasisen
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Vet Clin, Sch Vet Med &Anim Sci, BR-18618970 Sao Paulo, Brazil
dc.description.affiliationUnespDepartment of Veterinary Clinic, School of Veterinary Medicine and Animal Science, Univ. Estadual Paulista – UNESP, Botucatu 18618-970, São Paulo, Brazil
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dc.description.sponsorshipIdFAPESP: 2010/13774-6
dc.description.sponsorshipIdFAPESP: 2012/16426-1
dc.description.sponsorshipIdFAPESP: 2012/16068-0
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt[1][4][3][2]
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