NLRP1 L155H polymorphism is a risk factor for preeclampsia development
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Data
2015-06-01
Autores
Pontillo, Alessandra
Reis, Edione C.
Bricher, Pamela N.
Vianna, Priscila
Diniz, Solange
Fernandes, Karla S.
Chies, José A.
Sandrim, Valeria [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Wiley-Blackwell
Resumo
Problem: Augmented levels of IL-1 ss have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro-IL1 ss cleavage and IL-1 ss secretion. Aim of the study was to evaluate the association between polymorphisms in inflammasome'genes and preeclampsia. Method of study: Selected polymorphisms in inflammasome genes (NLRP1, NLRP3, CARD8, and IL1B) were analyzed in 286 Brazilian women with and 309 without preeclampsia. Results and Conlclusions: The NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR=1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder.
Descrição
Palavras-chave
IL-1 ss, Inflammasome, NLRP1, Preeclampsia
Como citar
American Journal Of Reproductive Immunology. Hoboken: Wiley-blackwell, v. 73, n. 6, p. 577-581, 2015.